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HD-DinoMoE: A Class-Aware Hierarchical Dual Mixture-of-Experts Network for Scleral Anomaly Segmentation in Complex Acquisition Scenarios
Announce Type: new Abstract: Traditional Chinese Medicine (TCM) ocular inspection provides empirical cues for assessing scleral surface anomalies, but its clinical use remains subjective and difficult to quantify. To support intelligent and quantifiable ocular inspection, this study presents the TCM-inspired Artificial Intelligence Ocular Auxiliary Diagnosis System (TAO) and focuses on pixel-level scleral surface anomaly segmentation. For clinical and user-acquired images affected by...
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Mitosis Detection in the Wild: Multi-Tumor and Context-Aware Generalization in the MIDOG 2025 Challenge
Announce Type: new Abstract: Automated mitosis detection is a well-established task in computational pathology. While previous benchmarks focused on scanner-induced domain shift, clinical "real-world" application requires models to be robust across the vast variance to be expected in the histological landscape. The MItosis DOmain Generalization (MIDOG) 2025 challenge was designed to evaluate algorithmic performance across unprecedented biological and contextual diversity.
mRNAutilus: Multi-Objective-Guided Discrete Generation of mRNA with Optimized Therapeutic Properties
arXiv:2605.31296v1 Announce Type: cross Abstract: Therapeutic mRNA design requires coordinating multiple interacting sequence features across the full transcript, where codon usage, untranslated regions (UTRs), and their coupling jointly determine stability, translation efficiency, and protein expression. Here, we present mRNA generation via unrolled trajectories and informed latent updates (mRNAutilus), a framework for simultaneous codon optimization and de novo UTR design directly from...
More than 800 feedback cases a year lodged with NParks over pet parrots as popularity grows in Singapore
More than 800 feedback cases a year lodged with NParks over pet parrots as popularity grows in Singapore Complaints ranged from excessive noise to concerns about animal welfare. Pet parrots may bring colour and chatter into homes, but they are also becoming a growing source of disputes between neighbours. The National Parks Board (NParks) received an average of more than 800 feedback cases involving pet parrots each year between 2021 and 2025, with complaints ranging from excessive noise to...
A cheap arthritis drug shows promise treating RSV in early study
A cheap arthritis drug shows promise treating RSV in early study An arthritis drug reduces the amount of RSV in human respiratory cells, but experts say it's too early to say if it will actually treat the common infection. A cheap, widely available painkiller used to treat conditions like arthritis can significantly reduce RSV in the human respiratory tract, an early-stage laboratory study suggests. Respiratory syncytial virus (RSV) is the number one reason infants end up in the hospital in...
Pathology-Targeted EP4 Agonism Reverses Fibrosis in a Rat Model of DMD
Duchenne muscular dystrophy (DMD) presents a critical therapeutic gap in adolescent patients, where fibro-fatty muscle replacement and depletion of the regenerative niche render existing interventions insufficient. Prostaglandin E2 signaling through the EP4 receptor stimulates muscle regeneration, but systemic off-target effects have limited clinical translation of EP4 agonism. We evaluated irodanoprost (IROD), a bone-targeted prodrug of an EP4-selective agonist, in a DMD rat model using...
Antibiotic resistance turns up in Australian horses, raising new concerns about animal and human infections
Antibiotic resistance turns up in Australian horses, raising new concerns about animal and human infections Sadie Harley Scientific Editor Robert Egan Associate Editor Research into a common environmental germ that can cause severe infections in people and animals has raised concern that horses are starting to develop antibiotic resistance towards it. The University of the Sunshine Coast study examined the prevalence of the bug P. aeruginosa in Australian wild birds, native wildlife,...
Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans
Background: Thoracic aortic aneurysm (TAA) is a life-threatening condition with an unpredictable lisk of rupture. Current clinical parameters have limited ability to accurately predict imminent rupture. Osteopontin (OPN) has been implicated in aortic aneurysm pathology, however, it role as a marker of imminent rupture remains.
Mickey Mouse and friends freeze Super Netball finals out of prime venue
analysis Super Netball Round-Up: Disney on Ice spoiled the sport's finals plans, so how does it secure better venues? In the penultimate round of the Super Netball season, the top four were locked in. The Adelaide Thunderbirds' success at Ken Rosewall Arena on Saturday, 66-60, saw them secure the minor premiership and knock the NSW Swifts out of finals contention.