Clonal
No mentions found
This entity hasn't been tracked yet, or Iris is still building its knowledge base.
Related Articles from SNS
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Satellite DNA Editing Enables Meiosis-Independent Chromosome Engineering
Chromosome-scale genome engineering in plants typically relies on locus-specific recombination during meiosis to select desirable outcomes, limiting its application in species with long generation times. Here, we show that CRISPR targeting of abundant satellite DNA enables multiplexed chromosome restructuring in aspen, generating diverse large-scale structural variants in the first generation. These megabase rearrangements remain mitotically stable through clonal propagation and regeneration...
From hybrids to 'virgin birth,' stick insects reveal stepwise loss of sex
From hybrids to 'virgin birth,' stick insects reveal stepwise loss of sex Lisa Lock Scientific Editor Robert Egan Associate Editor The evolution of sex remains one of biology's greatest puzzles. While sexual reproduction dominates across the animal kingdom, scientists still debate why it persists despite its high costs. Even more mysterious is the loss of sex in favor of asexual reproduction whereby females give birth to copies of themselves without any contribution from males.
Single cell transforms into cannibalistic 'supergiant,' swallowing its clones whole
Single cell transforms into cannibalistic 'supergiant,' swallowing its clones whole Lisa Lock Scientific Editor Robert Egan Associate Editor Researchers at Rensselaer Polytechnic Institute (RPI) have discovered a microscopic organism that can transform into a cannibalistic "supergiant" that drastically changes size, shape, and behavior, and abandons filter-feeding to hunt and consume their genetically identical relatives. The work, published on the cover of the Proceedings of the National...
How the body creates reliable antibodies out of biological chaos
How the body creates reliable antibodies out of biological chaos Sadie Harley Scientific Editor Robert Egan Associate Editor A new study tracking thousands of B cells across more than 100 germinal centers in mice reveals how the system consistently produces highly effective antibodies. The findings overturn longstanding ideas about how germinal centers function, revealing that they are far more selective than once thought, and challenges the idea that antibody improvement is driven mainly by...
Intraspecific genetic variation modulates immune responses to acute heat exposure in an aquatic ectotherm
Climate change-induced heatwaves threaten ectotherms, whose physiology is tightly coupled to ambient temperature. Vulnerability assessments often rely on data from one or a few populations, implicitly assuming uniform thermal sensitivity across species genetic diversity. Quantifying such variation is especially important for traits with wider ecological consequences; our focus here is on immune function, which shapes disease dynamics.
Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21
Correct neural progenitor cell (NPC) fate specification is essential to produce the full complement of neurons and glia needed for proper brain structure and function. Neurodevelopmental disorders, including the autosomal aneuploidy Down syndrome (DS), or Trisomy 21 (T21), are frequently associated with impaired cell fate decisions which ultimately drive differences in overall brain size and cell type composition through unknown mechanisms. To uncover mechanisms driving altered NPC fate in...
Multihospital expansion of vancomycin-resistant Enterococcus faecium ST117-CT7799 and transmission of linear plasmids co-carrying vanA and linezolid resistance genes, Comunitat Valenciana, Spain (2022-2024)
Background: Vancomycin-resistant Enterococcus faecium (VREfm) is a WHO priority pathogen. In the Comunitat Valenciana (CV), Spain, VREfm prevalence has increased since 2022. We characterized the population structure, transmission patterns and resistance determinants of VREfm across eight hospitals (2021-2024).
A Low-Cost, High-Throughput Design-Build-Test Pipeline for Engineering Genetic Systems: Stress Testing with Complex Structural Proteins
Genetic systems engineering is constrained by high DNA synthesis costs, assembly inefficiencies, and challenges in expressing complex proteins. To address these limitations, we developed a highly parallel, low-cost pipeline for the design, assembly, and functional screening of genetic systems, which we stress-tested on highly repetitive structural proteins, including spider silk, biocements, reflectins, and talins. The integrated pipeline combines computational genetic systems design,...