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Hepatic stearoyl-CoA desaturase-1 is specifically suppressed by dextran sodium sulfate but does not influence colitis sensitivity
The delta-9 desaturase stearoyl-CoA desaturase-1 (SCD1) catalyzes the conversion of saturated fatty acids to monounsaturated fatty acids (MUFA) and is highly expressed in liver and adipocytes. Previous studies have demonstrated that treating mice with dextran sulfate sodium (DSS), a chemical inducer of ulcerative colitis, results in severe downregulation of SCD1 in the liver. However, the specific role of hepatic SCD1 in modulating colitis severity, as well as the impact of DSS on SCD1 and...
The First Human-Based In Vitro Flow Loop and Quantification for Fetal Aortic Hemodynamics
arXiv:2606.06801v1 Announce Type: new Abstract: Coarctation of the aorta (CoA) is a common congenital defect that remains difficult to diagnose prenatally due to subtle and evolving anatomical features. In the fetus, the ductus arteriosus creates a dual-inflow configuration that generates complex three-dimensional flow patterns not captured by standard imaging. Improved characterization of fetal hemodynamics may enhance diagnostic accuracy beyond anatomy-based assessment.
S-nitrosylation of protein kinase A is required for its activation by GPCRs
Stimulation of many G protein-coupled receptors (GPCRs) increases cyclic adenosine monophosphate (cAMP) and nitric oxide (NO). While cAMP-dependent activation of protein kinase A (PKA) is a central regulatory mechanism, a parallel role for NO in GPCR transduction has not been established. Here we show that upon stimulation of multiple GPCRs in heart, brain, and fat, the regulatory subunits of PKA undergo enzymatic S-nitrosylation by SNO-CoA-assisted nitrosylase (SCAN).
SCD-dependent lipid metabolism licenses alternative macrophage activation and macrophage plasticity
Lipid metabolic reprogramming accompanies macrophage activation, yet our understanding of why macrophages profoundly reshape their lipid composition remains unclear. Here, we identify stearoyl-CoA desaturase (SCD) as a lipid-metabolic checkpoint required for the acquisition of the alternatively activated macrophage (AAM) cell state. We show that SCD maintains lipid desaturation balance by ensuring the conversion of newly synthesized saturated long-fatty acids (SFAs) into monounsaturated...
Indus Waters Treaty: Centre says Pakistan won't get 'a single drop' in coming years
NEW DELHI: Union jal shakti minister CR Patil on Tuesday said that the Narendra Modi government is working to ensure that Pakistan receives no water from the Indus river system in the coming years. Patil said the treaty had not been terminated but suspended, and that efforts were underway to stop water flowing across the border. “It still stands; rather, the treaty has been kept in abeyance.
Hepatic Acetate is an Essential Fuel for the Heart during Energy-Deprived States
Energy supply is fundamental to cardiac performance, yet the mechanisms by which the heart adapts to nutrient scarcity remain incompletely understood. Here, we identify acetate as a pivotal metabolic substrate that sustains cardiac contractile function during fasting-induced energy deficiency. Fasted mice reveal significant elevation of circulating acetate derived from hepatic fatty acid catabolism.
Developing engineering strategies to enhance the genetic stability of fatty alcohol-producing strains for production scale-up
Robust strain stability is essential for industrial-scale fatty alcohol production, as metabolic burden and toxicity not only constrain productivity but also create selective pressure for low-producing or non-producing subpopulations. This genetic instability leads to genetic heterogeneity and compromises strain performance during large-scale fermentation. In this study, we investigated the production stability of fatty alcohol-producing Yarrowia lipolytica strains and developed systematic...
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling
Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature. Yet how these diverse signals are molecularly integrated remains unknown. Here we show that clock, diet, and temperature cues converge on the orphan mitochondrial transporter, SLC25A34, to orchestrate thermogenic cycling of lipid synthesis and oxidation.