Collagen
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Related Articles from SNS
The biggest collagen study yet reveals what actually works
The biggest collagen study yet reveals what actually works A massive review of collagen research found that the supplements can improve skin elasticity and hydration while helping reduce osteoarthritis pain and stiffness. - Date: - June 5, 2026 - Source: - Anglia Ruskin University - Summary: - A major review of nearly 8,000 participants found that collagen supplements can improve skin health and ease osteoarthritis symptoms, especially when taken consistently over longer periods.
Correlative SHG-AFM imaging workflow for label-free quantitative analysis of collagen structure-function relationships
We present a user-friendly correlative second harmonic generation (SHG) and atomic force microscopy (AFM) imaging workflow for quantifying the nanomechanical properties of collagen in unfixed, unlabeled tissue sections. SHG Aligned Profiling for Elasticity and Segmentation or SHAPES utilizes SHG imaging to guide AFM force mapping, enabling label-free, anatomically specific selection of regions of interest, facilitating spatially resolved characterization of fibrous collagen morphology and...
Alginate-Coated Collagen Hydrogel Tubes for Scalable Cell and Biotherapeutic Particle Manufacturing
Efficient, scalable, and cost-effective production of mammalian cells and biotherapeutic particles remains a major challenge for both research and clinical applications. Conventional 2D and 3D culture systems suffer from low volumetric yields, poor scalability, and high costs. Previously, we developed collagen hydrogel tube microbioreactors (ColTubes) that support high-density, high-viability cell culture by preventing excessive cell aggregation and minimizing hydrodynamic stress.
Nuclear confinement from matrix stiffness drives epigenomic reprogramming of gingival fibroblasts
Periodontal disease is characterized by progressive degradation of the gingival extracellular matrix and loss of the physical confinement it imposes on resident stromal cells. In human periodontal tissue, ECM collagen integrity is inversely correlated with facultative nuclear histone acetylation in stromal cells. We hypothesized that matrix stiffness directly coordinates an epigenomic shift in stromal cells.
Primary cilia promote cardiac fibrosis and limit heart function after myocardial infarction
Cardiomyocytes die and do not regenerate after an injury such as a myocardial infarction (MI), a leading cause of mortality worldwide. Following MI, cardiac fibroblasts (CFs) proliferate and differentiate into myofibroblasts, which then produce increased collagen and extracellular matrix (ECM) leading to fibrosis. Fibrosis can weaken cardiac output via excessive stiffening and interference with electric signal transmission, but can also prevent wall rupture under load.
Organ-specific fibroblast dynamics revealed via an integrated experimental-computational framework
Fibrosis is a progressive pathological process driven by dysregulated fibroblast activity and excessive extracellular matrix deposition, leading to scarring, functional decline and eventually organ failure. Although fibroblasts are key mediators of fibrotic remodelling, it remains unclear whether their behaviours are conserved across tissues or organ specific. Here, we combine experimental and computational approaches to dissect fibroblast dynamics underlying cardiac and pulmonary fibrosis.
Kindlin-1 loss disrupts vascular and extracellular matrix organisation to sustain hypoxia in cutaneous squamous cell carcinoma
Kindlin-1, encoded by FERMT1, is an essential integrin co-activator that regulates cell extracellular matrix (ECM) adhesion, tissue architecture, and microenvironment signalling. Loss-of-function mutations in FERMT1 cause Kindler epidermolysis bullosa, which is strongly associated with aggressive cutaneous squamous cell carcinoma (cSCC). Although Kindlin-1 deficiency promotes hypoxia and invasion, the impacts on ECM-vascular organisation and oxygen homeostasis are not known.
Structural gradients and strain partitioning across the mouse Achilles tendon enthesis revealed by in situ X-ray scattering
Announce Type: new Abstract: The enthesis is the insertion site of tendon into bone and exhibits a high mechanical durability despite the large mismatch in material properties between the two tissues. This durability stems from gradients in composition, structure and organization on multiple hierarchical length scales. Despite extensive research on enthesis structure and mechanics, the local deformation mechanisms are poorly understood.
King Charles' daily breakfast that's good for your heart and skin
King Charles' daily breakfast that's good for your heart and skin This simple concoction includes four straightforward everyday ingredients Royal breakfasts are often associated with silver platters, smoked salmon and lavish spreads. But King Charles is said to favour a far simpler start to the day - one that nutrition experts say could be beneficial for both heart health and skin. According to Falstaff, the former Prince of Wales enjoys baked eggs with cheese, spinach and tomatoes, a...
Back-Focal-Plane Imaging and Linear Density Measurements Of Sub-Diffraction Sized Biological Filaments and Particles
arXiv:2506.08186v3 Announce Type: replace Abstract: Optical tweezers equipped with position detection allow for application of piconewton-scale forces and high-temporal-resolution measurements of nanometer-scale motion. While typically used for trapping microscopic objects, the optical tweezer detection pathway can also be used for a microscopy technique sensitive to nanometer-sized structures. Optical tweezers most commonly use back-focal-plane detection to determine the position of the...