Coronaviruses
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A phage display library to dissect antibody responses to human coronavirus spike proteins
Coronaviruses are widespread human pathogens with demonstrated pandemic potential. We developed a phage immunoprecipitation sequencing (PhIP-Seq) library, C-Spike, enabling the profiling of serum antibody responses to coronavirus spike proteins. The C-Spike library includes peptides from 49 Alpha- and Betacoronavirus spike proteins, including pandemic coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV), seasonal coronaviruses (HKU1, OC43, 229E, NL63), and selected animal coronaviruses of...
AI-designed universal coronavirus vaccine passes first human trial
AI-designed universal coronavirus vaccine passes first human trial - Date: - June 5, 2026 - Source: - University of Cambridge - Summary: - Scientists have successfully tested an AI-designed universal coronavirus vaccine in humans for the first time, finding it to be safe and well tolerated. The vaccine generated immune responses against multiple coronaviruses, including SARS-CoV-2, SARS, and related bat viruses with pandemic potential. By targeting features shared across an entire virus...
Conserved structural features of RNA export pores spanning the double membrane of arterivirus and coronavirus replication organelles
Corona- and arteriviruses are distantly related positive-stranded RNA virus families within the order Nidovirales. Both transform intracellular membranes into double-membrane vesicles (DMVs) that serve as replication organelles. Newly made viral RNA presumably exits DMVs through double-membrane-spanning molecular pores formed by coronavirus nsp3-nsp4 and arterivirus nsp2-nsp3.
Lab evolution recreates COVID's path to omicron in months, reveals key conditions
Lab evolution recreates COVID's path to omicron in months, reveals key conditions Sadie Harley Scientific Editor Robert Egan Associate Editor A key step in the origin of many pandemics occurs when an animal-borne virus infects humans and then evolves to spread more efficiently from person to person. That is why scientists and physicians keep a close watch on viruses that could jump from animals to humans, such as emerging strains of avian flu and bat coronaviruses, as well as viruses that...
New AI-designed ‘universal vaccine’ could future-proof humans against unknown viruses
A new AI-designed vaccine capable of protecting against entire families of viruses could transform how the world prepares for a future pandemic. A team of British researchers, led by scientists at the universities of Cambridge and Southampton in the United Kingdom, has developed the first vaccine designed entirely by artificial intelligence (AI) to be tested in humans. “Viruses like Influenza, Coronaviruses and the Ebola group are evolving continuously, and by the time vaccines are rolled...
Actually, the SAT Was Necessary After All
Zvezdelina Stankova has taught mathematics at UC Berkeley for nearly three decades. But in 2023, while teaching introductory calculus for the first time since the beginning of the coronavirus pandemic, she noticed that something was quite wrong. The bottom 25 percent of students were not just struggling with the coursework, Stankova told me; “people were in freefall.”
Tools to fight hantavirus show promise despite limited funding. Now researchers hope to continue
Tools to fight hantavirus show promise despite limited funding. Now researchers hope to continue Andrew Zinin Lead Editor When a rare but deadly rodent-borne virus struck passengers on a cruise ship and seemed to be spreading, there were no treatments for those who fell ill and no vaccines to protect others. That was the case even though it wasn't a novel germ that the world had never seen before, like the virus that caused the coronavirus pandemic.
African Development Bank Allots $650 Million for Uganda Railroad
KAMPALA, UGANDA - 2020/03/21: Locals walk along the train tracks in Namuwongo slum during the coronavirus outbreak. So far only 33 people have been confirmed to be infected with COVID-19 in Uganda, and less than 5,000 across Africa.
Remote work – not AI – is killing job prospects for the youth
Fresh college graduates frozen out of the job market shouldn't blame AI for their struggles, says the New York Federal Reserve. Instead, get angry at the rise of remote work. According to the Fed's analysis, youth unemployment has risen significantly since the coronavirus pandemic, and hasn’t receded in the same way that unemployment numbers for older, more experienced college graduates has in recent years.
More people are going hungry now than at the height of the pandemic
Food insecurity affects more families now than during the coronavirus pandemic, according to a new survey from the Federal Reserve Bank of New York. (Image credit: Mark Felix)