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UA-DCM: Uncertainty-aware Causal Decision Making via Effect Bound Decomposition

arXiv:2601.22736v2 Announce Type: replace Abstract: Causal inference from observational data can provide strong evidence for finding the best action in a decision-making scenario without having to perform expensive randomized trials. The causal effect of an action is often not pointwise identifiable even with infinite data due to unobserved confounding factors. Furthermore, having only finitely many samples adds another layer of uncertainty to causal effect estimation.

arXiv CS 1d ago

Dual-Cluster Memory Agent: Resolving Multi-Paradigm Ambiguity in Optimization Problem Solving

arXiv:2604.20183v2 Announce Type: replace Abstract: Large Language Models (LLMs) often struggle with structural ambiguity in optimization problems, where a single problem admits multiple related but conflicting modeling paradigms, hindering effective solution generation. To address this, we propose Dual-Cluster Memory Agent (DCM-Agent) to enhance performance by leveraging historical solutions in a training-free manner. Central to this is Dual-Cluster Memory Construction.

arXiv CS 7d ago

Karnataka: DKS's cabinet to debut with 10-20 ministers; Delhi talks continue

BENGALURu/NEW DELHI: The Congress high command, along with chief minister-designate D K Shivakumar and caretaker chief minister Siddaramaiah, held late-night discussions in New Delhi Sunday to finalise the composition of the new Karnataka cabinet. There are plans to induct between 10 and 20 ministers in the first phase, alongside Shivakumar's swearing-in on Wednesday. A senior party functionary said the initial list is nearly ready, with some additional names still under consideration.

Times of India 8d ago

A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...

Nature 20h ago

Last-minute parleys? Karnataka CM-designate DKS, Sidda meet Rahul & Kharge

The Congress high command on Tuesday held a crucial meeting with Karnataka CM-designate DK Shivakumar and caretaker chief minister Siddaramaiah to finalise the composition of the new state Cabinet ahead of the swearing-in ceremony scheduled for Wednesday. Congress President Mallikarjun Kharge and leader of opposition in Lok Sabha Rahul Gandhi chaired the meeting, which focused on finalising the Cabinet lineup, and nominations for upcoming Rajya Sabha elections, ANI reported. The meeting...

Times of India 8d ago