DMF
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Related Articles from SNS
DMF: A Deterministic Memory Framework for Conversational AI Agents
arXiv:2606.03463v1 Announce Type: new Abstract: Conversational AI agents require memory systems that are both scalable and semantically coherent across long interaction horizons. Existing approaches rely predominantly on large language model (LLM)-based summarisation at write time, which introduces non-determinism, escalating token costs, and opacity in pruning decisions. We present the Deterministic Memory Framework (DMF), a CPU-first approach that replaces generative memory compression...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...