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SIGMA 60-600mm f/4.5-6.3 DG DN OS Sport lens review
SIGMA 60-600mm f/4.5-6.3 DG DN OS Sport lens review Sigma’s 60-600mm Sport lens is one of the most versatile wildlife lenses around, but can its huge zoom range outweigh the heavy design? The Sigma 60-600mm f/4.5-6.3 DG DN Sport lens boasts one of the most versatile focal ranges on the market and effortlessly produces beautiful wildlife shots. The images are sharp, contrasty and true to life, but for us, the weight is a dealbreaker. - + Image quality is lovely - + Versatile focal length - +...
SIGMA 150-600mm f/5-6.3 DG DN OS Sport lens review
SIGMA 150-600mm f/5-6.3 DG DN OS Sport lens review How does this third-party lens compare to the native Sony equivalent? We tested both to see whether it’s worth going native or whether you should save your money. A very capable option for newer wildlife photographers looking for an affordable super-telephoto lens without sacrificing too much image quality. -
DN-Hypo-Pipeline: An AI-Driven Workflow for Hypothesis Generation via Large Language Models and Scientific Explanations
Announce Type: new Abstract: A scientific hypothesis is the first step in research and undergoes experimental validation, yet it also reflects a deep understanding of and reasoning about scientific phenomena. We introduce DN-Hypo-Pipeline, an AI-powered workflow based on large language models, designed to support structured scientific thinking and hypothesis generation by leveraging scientific explanations as prior knowledge. This pipeline assists researchers in deriving novel hypotheses...
Organoid-T cell co-cultures functionally stratify tumor-reactive T cells and their responses to immune checkpoint inhibitors
Tumor-reactive T cells (TRTs) are critical for anti-tumor immunity but are incompletely captured by current assays, which fail to reproduce tumor-specific antigen diversity. Here, we show that multiplex functional profiling of patient-derived tumor organoid-T cell co-cultures (PDOTs) enables robust identification of TRTs across CD8, CD4, and double-negative (DN) T cell populations. Single activation markers underestimated TRT responses, whereas integrated analysis revealed broader functional...
Boundary-compatible interacting approximations of quasilinear PDEs on bounded domains
arXiv:2606.04049v1 Announce Type: new Abstract: We develop a general operator-theoretic route that turns Kato-type quasilinear evolution systems on a Banach scale $(Z,X)$ into finite-dimensional interacting approximations. The construction proceeds in two steps. First, one introduces a regularized family $(A_\varepsilon,f_\varepsilon)$ indexed by a scale parameter $\varepsilon>0$, for which the drift $A_\varepsilon[t,z]z+f_\varepsilon[t,z]$ takes values in an output space $Y$ suitable for...