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Price Paid Data
Price Paid Data Download the Price Paid Data (PPD) in text or CSV format and access our linked data. Our Price Paid Data includes information on all property sales in England and Wales that are sold for value and are lodged with us for registration.
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Openrsync: An implementation of rsync, by the OpenBSD team
This system has been merged into OpenBSD base. If you'd like to contribute to openrsync, please mail your patches to [email protected]. This repository is simply the OpenBSD version plus some glue for portability.
Lignin to adipic acid in a high-yield chemical and biological redox process
Abstract Viable manufacturing pathways to produce bio-based chemicals from renewable feedstocks, such as lignin derived from plant biomass, are needed to decarbonize the chemicals manufacturing sector. Converting the recalcitrant lignin polymer to valuable bioproducts remains a longstanding challenge in biorefining, with the highest reported single-product yield from lignin currently around 20 wt% (refs. Most existing lignin depolymerization strategies target aryl–ether bond cleavage, which...
The Smart TV in Your LivingRoom Is a Node in the AIScraping Economy
The work at Include Security has us working with AI day in and day out (hacking it, using it, training it, etc). We’re all aware of the community-level opposition happening against datacenters, aimed at improving AI capabilities, being built recently. What you might not be aware of are the distributed efforts to train AI that could be using the devices inside your home.
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Castor: CERN Advanced STORage Manager
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How Artemis II livestreamed hi-def videos and images from the moon to Earth
How Artemis II livestreamed hi-def videos and images from the moon to Earth Gaby Clark Scientific Editor Robert Egan Associate Editor This April, humanity had front-row seats to space as the Artemis II Orion spacecraft transmitted crystal-clear footage of its historic journey around the moon from more than 250,000 miles (about 402,000 kilometers) back to Earth at speeds on par with home internet connections. The livestreaming of high-definition video and high-resolution photos of the moon...
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.