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Dual-Chassis Strategy for Bridging Adaptive Evolution and Rational Design for Synthetic Biology
Genome streamlining and pathway refactoring are powerful strategies for constructing controllable microbial chassis for both fundamental studies and applications. While rational design benefits from reduced genetic complexity, adaptive laboratory evolution (ALE) thrives on metabolic redundancy, creating a mismatch between optimal hosts for design and evolution. Here, we introduce a dual chassis framework (DUET) in which rational pathway construction and adaptive evolution are first carried...
Apollo’s Shutterfly Sweetens Debt as Investors Weigh AI Risk
Brad Goreski attends Shutterfly By Design Hosted By Brad Goreski at the Glass Houses on June 17, 2015 in New York City.
I Like Ferrari's Luce EV. But This Is Why It's Heartbreaking
Designed by Jony Ive and a host of ex-Cupertino colleagues, the Luce shows us what might have been had Apple made good on its $10 billion bet.
New tartan celebrates Scotland and United States’ ‘enduring connection’ ahead of World Cup
New tartan celebrates Scotland and United States’ ‘enduring connection’ ahead of World Cup - Bookmark - CommentsGo to comments A new tartan has been unveiled to commemorate Scotland’s enduring relationship with the United States, ahead of the nation’s 250th anniversary and its co-hosting of the upcoming World Cup. The design, crafted by Kaci McEwan, a student at Heriot-Watt University’s School of Textiles and Design in Edinburgh, was chosen to symbolise the deep historical and cultural bonds...
New tartan celebrates Scotland and United States’ ‘enduring connection’ ahead of World Cup
New tartan celebrates Scotland and United States’ ‘enduring connection’ ahead of World Cup - Bookmark - CommentsGo to comments A new tartan has been unveiled to commemorate Scotland’s enduring relationship with the United States, ahead of the nation’s 250th anniversary and its co-hosting of the upcoming World Cup. The design, crafted by Kaci McEwan, a student at Heriot-Watt University’s School of Textiles and Design in Edinburgh, was chosen to symbolise the deep historical and cultural bonds...
Modeling in vitro cell-to-cell spread of hepatitis C viral infection using an agent-based approach
Mechanisms that lead to viral chronicity are poorly understood, but cell-to-cell spread has been implicated in the establishment of chronic infections. We previously developed mathematical models to explore the nature of hepatitis C virus (HCV) cell-to-cell spread in vitro and quantified the effect of inhibiting individual host factors involved. However, the previous models were not designed to (i) address cell proliferation, (ii) account for differences in cell size, and (iii) did not...
UK's most 'bog standard' biscuit looks like this to 'trick' people
UK's most 'bog standard' biscuit looks like this to 'trick' people There's a reason why Britain's most 'bog standard' biscuit looks the way it does One of Britain's most classic creations, sold for less than £1 in most supermarkets, has kept a unique piece of history to this day. Few actually realise why the popular Custard Cream stands out with such an "ornate" design compared to other baked goods. On Instagram (@Theotherbritishmusuem), radio host Annabel Port explores obscure aspects of...
How an app is growing social connections for people with disability and caregivers
How an app is growing social connections for people with disability and caregivers Lisa Lock Scientific Editor Andrew Zinin Lead Editor Almost 1 in 3 Australians experiences loneliness. For people with disability and care workers, that number can be even greater. Many people living with disability face barriers to participating in physical activity, while caregivers often struggle to find time, social support and opportunities to look after their own well-being.
AXLE: Coordinated Offloading with Asynchronous Back-Streaming in Computational Memory Systems
arXiv:2512.04449v2 Announce Type: replace Abstract: CXL-based Computational Memory (CCM) enables near-memory processing within expanded remote memory, offering opportunities to address data movement costs in disaggregated memory systems and to accelerate overall performance. However, existing offloading mechanisms do not fully leverage the trade-offs of different offload models based on different CXL protocols. This work first examines these tradeoffs and their impact on end-to-end...