Developmental Biology
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'All-in-one' platform developed for multiple trait stacking in crops
'All-in-one' platform developed for multiple trait stacking in crops Gaby Clark Scientific Editor Alexander Pol Deputy Editor A major goal of modern crop breeding is to efficiently combine multiple desirable traits by "stacking" the favorable gene variants (alleles) that contribute to those traits in a single crop variety. However, current strategies are often time-consuming and inefficient. Now, a team led by Gao Caixia at the Institute of Genetics and Developmental Biology of the Chinese...
Embryonic tissues can behave like fluids or solids to reshape cell fate signals
Embryonic tissues can behave like fluids or solids to reshape cell fate signals Sadie Harley Scientific Editor Robert Egan Associate Editor Embryonic development is one of the most dynamic biological processes in nature. Cells and tissues organize and reorganize themselves following incredibly precise patterns, while remaining flexible and robust. Scientists are increasingly probing the role the physical properties of embryonic tissues—such as rigidity or stiffness—play in this process.
New 3D microscope technology captures high-resolution tissue images at a fraction of the cost
New 3D microscope technology captures high-resolution tissue images at a fraction of the cost Sadie Harley Scientific Editor Robert Egan Associate Editor A team led by Raju Tomer, professor of biological sciences at Columbia University, has created a new design for microscopes and microscope lenses that could push 3D tissue imaging beyond state-of-the-art systems while drastically cutting costs and complexity. Details of the design were published in the journal Nature Biotechnology. Modern...
A new origin story for multicellular life points to physics, not genes alone
A new origin story for multicellular life points to physics, not genes alone Sadie Harley Scientific Editor Robert Egan Associate Editor How did life make the leap from single cells to coordinated, multicellular organisms? And how do genetically identical cells still perform a version of that feat every time an embryo begins to take shape? In a new Perspective paper appearing in the journal Nature Biotechnology, Bren Professor of Biology and Biological Engineering Magdalena Zernicka-Goetz...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
The XenCart Protocol: A Method for Alcian Blue Labeling and Quantitative Analysis of Craniofacial Cartilage in Xenopus
Craniofacial birth defects, such as cleft lip and palate, are among the most common congenital anomalies and often arise from disruptions in early facial patterning. Many of these defects are linked to environmental teratogens, yet such exposures cannot be directly tested in humans, making animal models essential for evaluating developmental risks. Xenopus laevis offers a powerful solution: its tadpoles develop externally, share deeply conserved craniofacial patterning mechanisms with...
Development positions malignant cellular states but does notexplain their diversification
Epithelial cancers are often described as aberrant reactivations of embryonic or tissue-forming programs, but whether malignant cellular-state diversification is actually constrained by developmental trajectories remains unclear. Here, we present a quantitative framework to test this idea in pancreatic ductal adenocarcinoma (PDAC). Using representation learning on large-scale single-cell data, we build a reference space that captures the main axes of normal foregut and pancreatic epithelial...
Overlooked DNA structures help organize the genome
Overlooked DNA structures help organize the genome Lisa Lock Scientific Editor Robert Egan Associate Editor Northwestern Medicine scientists have discovered that little-studied DNA structures play a central role in organizing the human genome and controlling gene activity, according to a new study published in the Proceedings of the National Academy of Sciences. The study revealed that G-quadruplexes (G4s)—four-stranded DNA structures—directly interact with a key genome-organizing protein...
Girls with additional needs ‘at significant risk from social media algorithms’
Girls with additional needs ‘at significant risk from social media algorithms’ Exclusive: Girls with additional needs including special educational needs and mental health problems risk being sucked into a ‘cycle’ of harmful online content, report warns - Bookmark - CommentsGo to comments Social media algorithms are “exacerbating” the vulnerabilities of girls who have additional needs, leaving them exposed to “significant harm”, a new report has warned. Experts said girls with additional...
Advances in the management of ADHD in children and adolescents
AbstractThis review synthesizes evidence on managing attention deficit/hyperactivity disorder (ADHD) in children and adolescents, focusing on studies published between 2019 and 2025. Recent research supports a dimensional, pleiotropic model of ADHD characterized by heterogeneity, developmental fluctuation, and frequent comorbidity. ADHD is a chronic, fluctuating condition, underscoring the need for sustained and individualized care.