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Copper transport to mitochondria by SLC25A3 contributes to skeletal myoblast differentiation and is required for survival of differentiated myotubes
Differentiation of skeletal muscle is associated with increased mitochondrial biogenesis and reliance of oxidative phosphorylation (OXPHOS). The terminal enzyme complex in the electron transport chain, cytochrome c oxidase (COX), requires copper for its assembly and activity, and copper delivery to mitochondria is essential for OXPHOS. However, when mitochondrial copper becomes essential during skeletal myoblast differentiation is not known.
Mathematics of Spacetime: A Guided Tour Through The Underlying Differential Topology and Differential Geometry
arXiv:2606.02616v1 Announce Type: new Abstract: Background in General Relativity (e.g. black holes, wormholes, or spacetime models in general) is needed to comprehend more recent efforts around understanding quantum phenomena like entanglement (e.g. >>It from qubit>ER = EPR<<). The former in turn requires a lot of knowledge from differential topology and differential geometry. While this knowledge is available in very good mathematics textbooks, it is scattered i.e. quite a bunch of sources...
Differentiable Optimization of Linear Differential Microphone Arrays: A Joint Geometry and Filter Design Framework
arXiv:2412.05123v2 Announce Type: replace Abstract: This paper presents a differentiable optimization framework for the design of constrained Linear Differential Microphone Arrays (LDMAs). The proposed method leverages a non-uniform delay-and-sum beamformer as a light-weight base system model, proving its ability to achieve the optimal beampattern of LDMAs by jointly optimizing microphone positions and filter weights. The formulation enables the optimized design of a filter with a...
Nonlinear numerical schemes using specular differentiation for initial value problems of first-order ordinary differential equations
arXiv:2601.09900v4 Announce Type: replace Abstract: This paper proposes specular differentiation in one-dimensional Euclidean space and provides its fundamental analysis, including a quasi-Fermat theorem and a quasi-Mean Value Theorem. As an application, this paper develops several numerical schemes for solving initial value problems for first-order ordinary differential equations. Based on numerical simulations, we select one scheme and prove its second-order consistency and convergence.
Optimal conversion from R\'enyi Differential Privacy to $f$-Differential Privacy
arXiv:2602.04562v3 Announce Type: replace Abstract: We prove the conjecture stated in Appendix F.3 of \citet{zhu2022optimalaccountingdifferentialprivacy}: among all conversion rules that map a R\'enyi Differential Privacy (RDP) profile $\tau \mapsto \rho(\tau)$ to a valid hypothesis-testing trade-off $f$, the rule based on the intersection of single-order RDP privacy regions is optimal. This optimality holds simultaneously for all valid RDP profiles and for all Type I error levels $\alpha$....
A pictorial introduction to differential geometry (2017)
Differential Geometry [Submitted on 21 Sep 2017] Title:A pictorial introduction to differential geometry, leading to Maxwell's equations as three pictures View PDFAbstract:In this article we present pictorially the foundation of differential geometry which is a crucial tool for multiple areas of physics, notably general and special relativity, but also mechanics, thermodynamics and solving differential equations. As all the concepts are presented as pictures, there are no equations in this...
DP4SQL: Differentially Private SQL with Flexible Privacy Policies
arXiv:2606.07883v1 Announce Type: new Abstract: The plausible deniability model of differential privacy for single-table datasets is well-understood. However, applying differential privacy to relational databases is much trickier: each application needs flexibility in specifying the pieces of information about an entity, spread across multiple relations, that require plausible deniability guarantees. Existing differentially private SQL systems only support rigid privacy policies.
Suppression of differential light shifts in ground and metastable trapped-ion qubits
arXiv:2606.02543v1 Announce Type: new Abstract: In the presence of a magnetic field, hyperfine clock qubits can acquire a vector differential light shift that can be tuned via polarization to suppress the total differential light shift of high-power, off-resonant laser light. We experimentally measure this "magic" polarization condition, suppressing differential light shifts in both the ${}^2\mathrm{S}_{1/2}$ ground and ${}^2\mathrm{F}_{7/2}^o$ metastable clock qubits of...
Membership Reference Attack against Laplace Mechanism of Differential Privacy
arXiv:2409.08784v4 Announce Type: replace Abstract: The differential privacy is a widely accepted conception of privacy protection and the Laplace mechanism is a famous instance of differential privacy mechanisms to deal with numerical data. In this paper, we point out that the differential privacy does not take liner property of queries into account, resulting in information leakage. In order to show the information leakage, we construct a membership reference attacks against the Laplace...
EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA
Enteroendocrine cells (EECs) are specialized sensors of the gastrointestinal (GI) epithelium that regulate gut function and systemic metabolism through hormone secretion. The molecular pathways directing intestinal stem cell (ISC) differentiation into EECs are incompletely understood due, in part, to their rarity. We sought to identify novel regulators of human EEC differentiation using a high-throughput screen of FDA-approved drugs and human duodenal organoids.