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EndoTwin-W: glycodelin-A and CA-125 as non-invasive biomarkers of endometrial receptivity derived from a multiscale computational digital twin

Endometrial receptivity assessment currently requires invasive tissue biopsy, yet recent randomized trials have questioned the clinical utility of biopsy-based approaches. Here we present EndoTwin-W, a four-layer mechanistic computational model that simulates human endometrial remodeling from hormone inputs through receptor binding, pathway scoring, and continuous-time Markov chain cell-state transitions across 17 cell states. Transition rates were optimized against scRNA-seq and microarray...

bioRxiv 11d ago

Digital Quantum Reservoir Computing for ATM Time Series Prediction

arXiv:2606.04686v1 Announce Type: cross Abstract: We investigate a digital quantum reservoir computing (QRC) framework for multi-step forecasting of automated teller machine (ATM) cash demand time series on near-term quantum devices. The proposed approach uses parametrized four-qubit reservoirs with a fixed structure exploiting partial measurement and reset, where temporal data is encoded in rotation angles. Training is restricted to a classical Ridge-regression readout.

arXiv CS 6d ago

A Variational Framework for the Complexity of PDE Solutions

arXiv:2510.21290v3 Announce Type: replace Abstract: Partial Differential Equations (PDEs) are fundamental mathematical models for describing physical phenomena, yet most PDEs of practical interest require numerical approximations. The feasibility of such methods is constrained by existing computational models. Since digital computers are the primary realizations of numerical computations, and Turing machines define their theoretical limits, computability of PDE solutions is of fundamental...

arXiv CS 1d ago

Spain and EU launch new €10 million quantum computer in Barcelona

This supercomputer, located at Barcelona's BSC-CNS centre, can combine classical computing with both digital and analogue quantum computing.

Euronews 12d ago

Compact and Energy-Efficient Memristive Spiking Neuromorphic Accelerator for Bio-inspired Interception Tasks

arXiv:2605.31141v1 Announce Type: new Abstract: Spiking neural networks (SNNs) provide an efficient event-driven computing paradigm for bio-inspired interception tasks. However, most implementations rely on von Neumann digital computing platforms, where memory and computation bottlenecks limit energy efficiency. This work presents a compact and energy-efficient memristive neuromorphic accelerator for bio-inspired interception tasks.

arXiv CS 9d ago

Computational conceptual history of scientific concepts: From early digital methods to LLMs

arXiv:2606.04118v1 Announce Type: new Abstract: This article situates large language models (LLMs) within the longer history of computational approaches to concept analysis in the history, philosophy, and sociology of science (HPSS). We examine what LLMs add to existing methods, how they inherit longstanding problems, and review recent case studies that employ them. In the first part, we reconstruct computational conceptual history before LLMs by bringing together three strands of work:...

arXiv CS 6d ago

AutoNumerics-Zero: Automated Discovery of State-of-the-Art Mathematical Functions

Announce Type: replace Abstract: Transcendental functions, such as the exponential, are central to scientific computing, yet they cannot be natively calculated by digital hardware. Instead, computers must approximate these functions by combining basic operations, such as $\{+, -, \times, \div\}$, using methods like Taylor series. These methods were developed over centuries by mathematicians, who focused on approaches that could attain arbitrary accuracy.

arXiv CS 6d ago

Accuracy-Configurable Floating-Point Multiplier Design for SRAM-Based Compute-in-Memory

arXiv:2606.08430v1 Announce Type: new Abstract: Digital Compute-in-Memory (DCiM) reduces data movement and has become a promising solution for energy-efficient edge AI. However, most existing DCiM frameworks still primarily target integer or fixed-point arithmetic, and provide limited support for compiler-integrated and accuracy-configurable floating-point computation. Directly integrating conventional IEEE 754 floating-point units into dense SRAM-based DCiM arrays, however, incurs high area...

arXiv CS 1d ago

Lossy Microwave Linear Analog Computer (MiLAC) for Future MIMO: Learning-based Architecture Designs for Spectral and Energy Efficiency Maximization

arXiv:2606.02369v1 Announce Type: cross Abstract: Microwave linear analog computers (MiLACs) offer a transformative paradigm for future multiple-input multiple-output (MIMO) systems by shifting complex signal processing into the analog domain, thereby significantly reducing computational complexity, radio-frequency chains, and analog-digital converters, while speeding up computation. However, the practical deployment of MiLACs is severely constrained by the inherent hardware losses of the...

arXiv CS 8d ago

Q-FE: A Quantum-Native 6G Far-Edge Architecture Securing Industrial IoT Digital Twins via CSIDH-PQC and Asynchronous Federated Learning

arXiv:2606.03611v1 Announce Type: new Abstract: Sixth-generation (6G) wireless networks will underpin ultra-dense Industrial IoT (IIoT) ecosystems in which resource-constrained Far-Edge devices -- autonomous mobile robots, industrial actuators, connected vehicles -- must simultaneously satisfy sub-millisecond latency, $10^{-7}$-class reliability, and decades-long cryptographic security. Current architectures delegate Digital Twin (DT) computation to centralised cloud or Mobile Edge Computing...

arXiv CS 7d ago