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A genetic tool targeting brain GPR75

G-protein-coupled receptor 75 (GPR75) has emerged as an important mediator in diet-induced obesity (DIO) and a promising therapeutic target for anti-obesity drugs. However, the anatomical location of GPR75 in the brain remains unclear, hindering the understanding of GPR75 biology in DIO. Here, we generated a new GPR75-GFP-Ires-Cre knockin mouse strain, in which the Cre expression is driven by the endogenous GPR75 promoter and the GFP is fused with the C-terminal of the GPR75 protein.

bioRxiv 8d ago

The SLAX Scripting Language: An Alternate Syntax for XSLT

This section includes discussion of SLAX language issues. XPath expressions use a style of type promotion that coerces values into the particular type needed for the expression. For example, if a predicate refers to a node, then that predicate is true if the node exists.

Hacker News 11d ago

Guadalajara: A travel guide to the 2026 World Cup host city

Mexico's second-largest city is hosting its third men's World Cup after previously staging matches in 1970 and 1986. Known for its mariachi music and for being a gateway to Mexico's tequila country, Guadalajara promises an authentic experience for football fans travelling to the 2026 FIFA World Cup. Located in the state of Jalisco, Mexico's second-largest city will host four World Cup group-stage matches at Estadio Akron, which will be known as Guadalajara Stadium during the tournament,...

Euronews 3d ago

ESP32 Bit Pirate, a Hardware Hacking Tool with WebCLI That Speaks Every Protocol

ESP32 Bit Pirate is an open-source firmware that turns your device into a multi-protocol hacker's tool, inspired by the legendary Bus Pirate. It supports sniffing, sending, scripting, and interacting with various digital protocols (I2C, UART, 1-Wire, SPI, etc.) via a serial terminal or web-based CLI.

Hacker News 5d ago

22 World Cup items, 22 stories

FIFA won't reveal how, but after every game at the 2026 World Cup this summer, it will be collecting items that will one day document the tournament. It already has the net from the 2018 World Cup final, for example, as well as the tracksuit that Pelé wore at his first World Cup in 1958. The items live in FIFA's various museums, ranging from Vancouver and Miami to Zurich and Hong Kong.

ESPN 3d ago