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Deep Proteoform Sequencing with Top-Down Direct Mass Technology

Individual Ion Mass Spectrometry (I2MS) using Direct Mass Technology mode on an Orbitrap mass spectrometer (DMTm) increases sensitivity, resolution, and mass range for protein analysis. Here, we present an end-to-end workflow for deep proteoform sequencing using top-down mass spectrometry with DMTm. By assigning the charge of individual fragment ions and converting spectra from the m/z to the mass domain, DMTm resolves overlapping isotopic distributions that have limited conventional...

bioRxiv 7d ago

WiiM's first soundbar has a touchscreen display and Dolby Atmos

WiiM's first soundbar has a touchscreen display and Dolby Atmos The $479 WiiM Bar arrives next month. There are a lot of options for Dolby Atmos soundbars these days, but WiiM is hoping one particular element of its 3.0.2-channel, eight driver soundbar will woo the masses.

Engadget 7d ago

Astronomers measure the mass of a dormant black hole, our solar system's lost protoplanet, and more science stories

Astronomers measure the mass of a dormant black hole, our solar system's lost protoplanet, and more science stories This week's science news. It's been an eventful week in science news. Astronauts on the ISS were briefly ordered to shelter in place after the discovery of an air leak in the transfer tunnel, NASA officially declared its MAVEN space probe dead and scientists announced the creation of a "universal vaccine" designed by AI.

Engadget 3d ago

Leiden Declaration on Artificial Intelligence and Mathematics

Declaration text Leiden Declaration on Artificial Intelligence and Mathematics Preamble Technological developments have repeatedly transformed the practice of mathematics. Recent artificial intelligence technologies, including symbolic and neural methods for the generation and formalization of mathematics, may already have initiated a significant chapter in this long history. Among researchers, artificial intelligence has produced a wide range of reactions: enthusiasm for its potential to...

Hacker News 7d ago

How do you study an invisible exoplanet? Astronomers discover planetary 'fingerprints' in the rings around stars

How do you study an invisible exoplanet? Astronomers discover planetary 'fingerprints' in the rings around stars You just have to read between the rings. How do you weigh a planet you can't see from many light-years away?

Space.com 8d ago

Low Level RF and Timing System Design for the Cool Copper Collider

arXiv:2606.06630v1 Announce Type: new Abstract: The Cool Copper Collider (C3) is a linear accelerator (LINAC) concept based on compact, high gradient, and normal conducting accelerator technology to support Higgs boson studies at 250 GeV and 550 GeV center of mass. The C3 accelerator is ten kilometers in scale and consist of 2,200 RF stations for 550 GeV center of mass. To maintain the stringent beam quality required by the collider across the LINACs, each of the cavities has a dedicated...

arXiv Physics 2d ago

Everyone thought these helmets were Roman until scientists uncovered the truth

Everyone thought these helmets were Roman until scientists uncovered the truth A "Roman" helmet treasure hidden beneath the sea for centuries has been revealed as evidence of a vast medieval weapons trade network. - Date: - June 8, 2026 - Source: - University of Alicante - Summary: - Researchers have solved a decades-old mystery by showing that a cache of 43 helmets found off the Spanish coast is medieval, not Roman.

Science Daily 2d ago

Fast-moving droplets synthesize key drug compounds at room temperature, no catalysts needed

Fast-moving droplets synthesize key drug compounds at room temperature, no catalysts needed Lisa Lock Scientific Editor Robert Egan Associate Editor Chemical reactions are the backbone to nearly all biological processes, including those used to make new medicines. However, these reactions can often take considerable time and require harsh conditions or materials—potentially inhibiting the timely development of life-changing drugs. Purdue University researcher Graham Cooks and his team at...

Phys.org 8d ago

How tuning atomic order and surface chemistry can shape MXenes

How tuning atomic order and surface chemistry can shape MXenes Sadie Harley Scientific Editor Robert Egan Associate Editor Scientists at the U.S. Department of Energy's (DOE) Argonne National Laboratory are helping show what it means to design a material almost atom-by-atom. In two publications, scientists show they can carefully choose the types of atoms in a material, where those atoms sit and what is attached to the surfaces of its atom-thin layers. That level of control lets them tailor...

Phys.org 5d ago

Is extracting oxygen from lunar soil the future of space exploration?

Is extracting oxygen from lunar soil the future of space exploration? Lisa Lock Scientific Editor Andrew Zinin Lead Editor A new race to the moon is emerging between the United States and China.

Phys.org 10d ago