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Context-dependent modulation of social space by dopamine receptors in the Drosophila melanogaster mushroom body
Social behavior takes many forms, yet the fundamental principles of social circuit function are thought to be evolutionarily conserved. Foundational behaviors that precede more complex interactions can reveal the mechanisms underlying these circuits. Social spacing, the regulation of preferred inter-individual distances, is one such behavior and can be quantified in the genetically tractable model Drosophila melanogaster.
Proximity labelling of D1-like dopamine receptors reveals distinct cellular environments and uncovers trafficking proteins that regulate DA mediated behaviors in Drosophila
The neurotransmitter dopamine (DA) is central to synaptic regulation that support diverse behavioral functions, including both learning and forgetting. This multi-functional role of DA is due to receptor specific signaling in specific subcellular environments that remain uncharacterized. Here we utilized proximity labelling proteomics in human cells to characterize the proximal environments of two Drosophila D1-like DA receptors (Dop1R1 and Dop1R2) in basal and DA activation environments.
Two Genomes, One Metabolome: Mitonuclear Incompatibility Remodels Developmental Metabolism and Fitness in Drosophila
Mitochondrial-nuclear (hereafter mitonuclear) genetic variation can alter cellular bioenergetics and metabolism via jointly encoding the subunits of oxidative phosphorylation (OXPHOS) system. Here we tested whether genetic variation in biochemical and bioenergetic phenotype can scale up across higher levels of biological organization to affect organismal development. We used a panel of (mtDNA); nDNA genotypes created by asymmetric substitution of divergent mtDNA between Drosophila...
Vesicular pseudopodia define the fusion site on large secretory vesicles of the Drosophila salivary glands
Large secretory vesicles (LSVs) pose a scaling problem for regulated exocytosis. Their micron-scale dimensions greatly increase the vesicular membrane surface area, making productive engagement between the vesicular and target membrane fusion machinery unlikely. Here, we show that vesicular pseudopodia define the fusion sites of LSVs in Drosophila larval salivary glands.
Dual-channel whole-brain imaging reveals distinct dopamine and calcium dynamics in walking Drosophila
Simultaneous recording of intra- and extracellular neuronal signals across the brain during behavior is crucial for unraveling brain information processing. In Drosophila, large-scale recordings have been explored, yet simultaneous dual-channel whole-brain imaging remains a significant challenge. We developed a system combining a Fourier light-field microscope with dual-focal microlens arrays optimized for adult walking flies, extending imaging volume while maintaining resolution requirements.
Fat body driver expression report across Drosophila melanogaster tissues and sex
Drosophila melanogaster serves as a valuable model system for advancing our understanding of adipose tissue given its analogous organ systems, conserved metabolic, endocrine, and nutrient-sensing functions, and well-established genetic tools. Among the most widely used genetic tools is the Gal4/UAS system. Several Gal4 driver lines are reported to control expression in the D. melanogaster fat body, but secondary expression sites and responses to physiological changes have not been fully...
A nanoscale atlas of extracellular vesicles and particles in Drosophila olfactory sensilla
Extracellular particles, including non-vesicular extracellular particles (NVEPs) and extracellular vesicles (EVs), are emerging as key contributors to sensory signaling, yet their ultrastructural organization within native tissues remains underexplored. Native tissues preserve extracellular particle organization and heterogeneity that are often lost during dissociation. Using cryofixation-based serial block-face scanning electron microscopy, we generated a nanoscale atlas of NVEPs and EVs...
Modes of natural selection on maternal and zygotic gene expression in Drosophila melanogaster embryos
Early embryonic development involves the coordination of gene expression from two distinct genomes, as mothers load eggs with gene products prior to the beginning of zygotic transcription. Because the maternal transcriptome is controlled by the mothers regulatory genotype rather than that of the embryo, these two sequential developmental programs may experience distinct evolutionary constraints and selection pressures despite both existing within the embryo. To infer modes of selection on...
Flightless I and LRRFIP work together to regulate lateral growth of the sarcomeres in Drosophila
Myofibrils are structurally highly conserved elements of the cardiac and striated muscles. The striking commonalities in their basic organization principles emerge during myofibrillogenesis when the initially formed premyofibrils grow in length and width to attain their final dimensions, characteristic of each muscle type. Although the molecular composition of the myofibrils is well known, the mechanisms governing their growth remain poorly understood, particularly those driving peripheral...
Segmentation gene expression and function in Vanessa cardui, an emerging model for Lepidoptera
Although all insects are segmented, the genes that control this process vary across species. Many of the pair-rule (PR) genes that direct segment formation in Drosophila are similarly utilized in other holometabolous insects, but more distantly related species use different genes for PR-patterning. Previously, we showed that Lepidoptera lack a highly conserved PR-gene, paired.