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EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA

Enteroendocrine cells (EECs) are specialized sensors of the gastrointestinal (GI) epithelium that regulate gut function and systemic metabolism through hormone secretion. The molecular pathways directing intestinal stem cell (ISC) differentiation into EECs are incompletely understood due, in part, to their rarity. We sought to identify novel regulators of human EEC differentiation using a high-throughput screen of FDA-approved drugs and human duodenal organoids.

bioRxiv 5d ago

Simultaneous Multi-objective Alignment Across Verifiable and Non-verifiable Rewards

arXiv:2510.01167v2 Announce Type: replace Abstract: Aligning large language models to human preferences is inherently multidimensional, yet most pipelines collapse heterogeneous signals into a single objective. We seek to answer what it would take to simultaneously align a model across various domains spanning those with: verifiable rewards, non-verifiable subjective preferences, and complex interactive scenarios.

arXiv CS 8d ago

WRIT: Write-Read Intensive Trajectory Synthesis for Multi-Turn User-Facing Agents

arXiv:2606.02908v1 Announce Type: new Abstract: Multi-turn user-facing agents must infer user intent from incomplete requests, collect missing information through dialogue and tools, and execute valid actions. A training trajectory records this process as an interleaved sequence of user messages, agent responses, tool calls, etc. Synthesizing sufficiently complex trajectory has become a central route to train agents: existing pipelines often increase difficulty by composing multiple user...

arXiv CS 7d ago

The Death of the Reader

Although I teach and edit fiction, I still didn’t think it would ever happen—that an AI-generated or AI-assisted short story would win a major contest. Then came Jamir Nazir’s “The Serpent in the Grove,” a regional winner of the Commonwealth Short Story Prize, published on Granta magazine’s website. The story exhibits all the common AI-writing “tells” familiar to anyone who has ever scrolled through a restaurant’s Instagram feed.

The Atlantic 6d ago

Support for rural women entrepreneurs linked to economic growth

Support for rural women entrepreneurs linked to economic growth Gaby Clark Scientific Editor Andrew Zinin Lead Editor Though rural women entrepreneurs make up only a small portion of the self-employed across the United States, new West Virginia University research shows they are crucial to overall economic success. A study by Heather Stephens, director of the WVU Regional Research Institute, and Xiaoyin Li, a postdoctoral fellow, with Jason S. Entsminger, assistant professor of...

Phys.org 23h ago