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Related Articles from SNS
Reliable Viscosity Calculation from High-Pressure Equilibrium Molecular Dynamics: Case Study of 2,2,4-Trimethylhexane
Announce Type: replace Abstract: Viscosity is a fundamental property of liquid lubricants, yet it is challenging to determine accurately, especially at high pressures. Although equilibrium molecular dynamics (EMD) simulations are a promising alternative to resource-intensive experiments, practical challenges remain in assessing the sufficiency of simulation time and in controlling uncertainties in the Green-Kubo formalism due to the finite amount of trajectory data. In this work, we extend...
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Gold, silver and bitcoin fall as traders up Fed rate hike bets
Precious metals were among the assets firmly in negative territory on Wednesday, as fears about inflation and the Federal Reserve's interest rate path weighed on investor sentiment. ET, spot gold was down 2.4% to trade at around $ 4,161.63 an ounce. U.S. gold futures also fell 2.2% to settle at $ 4,194.90/oz.
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Köln 75 review – how a legendary jazz-improv show was cajoled into being by a German teenager
Watchable biopic charts how an 18-year-old German booked the sickly American pianist Keith Jarrett for what became a landmark concertHere is a niche drama about one of the most important chapters in the history of experimental jazz. It is however watchable, well acted and avoids the music-movie cliches – though I could have done without the fourth-wall-breaking lectures about the nature of jazz improvisation. They were perhaps inspired by similar setpieces in Adam McKay’s financial crisis...
Köln 75 review – how a legendary jazz-improv show was cajoled into being by a German teenager
Watchable biopic charts how an 18-year-old German booked the sickly American pianist Keith Jarrett for what became a landmark concertHere is a niche drama about one of the most important chapters in the history of experimental jazz. It is however watchable, well acted and avoids the music-movie cliches – though I could have done without the fourth-wall-breaking lectures about the nature of jazz improvisation. They were perhaps inspired by similar setpieces in Adam McKay’s financial crisis...
A Systematic Evaluation of Current Architectures in Wind Power Forecasting
arXiv:2606.02849v1 Announce Type: new Abstract: Interval wind speed forecasting is essential for the efficient integration of wind energy into power systems, as it accounts for the inherent uncertainty of wind resources. This study presents a systematic literature review focused on hybrid approaches to interval forecasting of wind generation, exploring the combination of deep learning, modal decomposition, and statistical methods. To guide the paper selection, Latent Dirichlet Allocation...