European Spallation Source

First human SMUG1 atomic snapshots reveal how cells repair DNA

First human SMUG1 atomic snapshots reveal how cells repair DNA Sadie Harley Scientific Editor Robert Egan Associate Editor Researchers have captured the first atomic structures of human SMUG1, an enzyme that helps cells repair damaged DNA. The findings provide new insight into how cells recognize and remove harmful DNA bases, and may support future efforts to develop drugs that target this DNA repair pathway. "These structures give us the first detailed view of how human SMUG1 engages...