Exosomes
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Gut Microbiota Dysbiosis Drives Myocardial Hypertrophy Through GBP2b/GBP1-Mediated Immune Reprogramming and Exosomal Signaling in Chronic Colitis
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk of cardiovascular disease, yet the mechanisms linking chronic intestinal inflammation to cardiac dysfunction remain poorly understood. IBD is characterized by profound gut microbiota dysbiosis, which we hypothesize drives systemic immune dysregulation and contributes to cardiac dysfunction. A chronic colitis mouse model was used to assess gut microbiota dysbiosis, systemic immune cell metabolism, and cardiac...
Hidden tick saliva protein may help stop disease spread at source
Hidden tick saliva protein may help stop disease spread at source Andrew Zinin Lead Editor Few creatures inspire as much universal dislike as ticks. Though small, these parasites have an enormous impact on human and animal health. Each year, ticks spread viruses and bacteria that infect people, livestock, wildlife, and pets around the world.