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GAPVD1 regulates CSNK1D-dependent PER2 FASP phosphorylation

The mammalian circadian clock relies on precisely timed transcriptional and post-translational events to generate ~24-hour rhythms. A key post-translational mechanism is phosphorylation of PER2 by CSNK1D, governed by a phosphoswitch that integrates stabilizing and destabilizing phosphorylation marks at the FASP and Degron sites to control PER2 stability and circadian period. Here, a novel role for the PER complex protein GAPVD1 in regulating CSNK1D-mediated FASP site phosphorylation is revealed.

bioRxiv 10d ago

Antenatal screening standards: data report 2024 to 2025

Antenatal screening standards: data report 2024 to 2025 Data report for fetal anomaly screening, infectious diseases in pregnancy screening and sickle cell and thalassaemia screening 1 April 2024 to 31 March 2025. Applies to England Documents Details This publication covers the 3 NHS population antenatal screening programmes: These are the: - NHS Fetal Anomaly Screening Programme (FASP) - NHS Infectious Diseases in Pregnancy Screening (IDPS) Programme - NHS Sickle Cell and Thalassaemia (SCT)...

GOV.UK Statistics 8d ago