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Optical genome mapping identifies source-associated structural variant differences across early-passage human iPSCs

Background: Induced pluripotent stem cells (iPSCs) are an important model for studying human diseases in vitro. However, previous studies have shown that iPSC reprogramming and extended cell culture can introduce genomic structural variants (SVs). Technologies like karyotyping, CNV microarrays, and whole-genome sequencing have limitations in resolution, sensitivity, or the ability to detect large and complex structural variants compared to optical genome mapping (OGM).

bioRxiv 10d ago

Control Resonant will bend your reality on September 24, 2026

Control Resonant will bend your reality on September 24, 2026 You can pre-order the Faden siblings' next adventure now. It's been about five months since our last look at Control Resonant, the much-anticipated sequel to 2019's Control from Remedy Entertainment, and now we know when it'll arrive: September 24, 2026. The date was announced as part of the PlayStation State of Play event today, but it'll also hit the Xbox Series X/S and PC.

Engadget 7d ago

Control Resonant's take on New York feels like the Backrooms

Control Resonant's take on New York feels like the Backrooms We played the opening of the Control sequel and saw just how weird Remedy's twisted city is. Remedy Entertainment is taking a very bold approach for the sequel to 2019's Control. Focusing on a new protagonist stepping out into a weird, corrupted version of New York City, Control Resonant shifts to a more open-ended action-RPG that dives deep into punchy melee combat.

Engadget 4d ago

Superdrug launches new service that helps anyone feeling tired 'all the time'

Superdrug launches new service that helps anyone feeling tired 'all the time' The new UK high-street service is designed to help people with common health issues Superdrug has announced the launch of a new service for shoppers, available nationwide in stores. The new service marks a UK high street first and is aimed at people who suffer from common health conditions, helping them get to the root cause. For £109, shoppers can get Superdrug's new Skin Health Blood Test.

Daily Mirror 1d ago