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Fischer 344

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Central auditory decline precedes cochlear deficits in a D-galactose mimetic model of aging

Age-related hearing loss reflects a mixture of concurrent peripheral cochlear and central auditory pathway degeneration. Disentangling their relative contributions has remained challenging because both decline together with natural aging. Here, we used systemic D-galactose (D-gal) administration to selectively accelerate central auditory aging while preserving peripheral cochlear function.

bioRxiv 7d ago