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A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
UR-JEPA: Uniform Rectifiability as a Regularizer for Joint-Embedding Predictive Architectures
arXiv:2606.01443v1 Announce Type: new Abstract: A central difficulty in training Joint-Embedding Predictive Architectures (JEPAs) is preventing representation collapse. LeJEPA addresses this by enforcing an isotropic Gaussian target on the embeddings via Sketched Isotropic Gaussian Regularization (SIGReg). This target is in tension with the manifold hypothesis, which expects embeddings to concentrate on a low-dimensional subset of the ambient space.
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Kalshi wants small businesses to hedge like Wall Street. A NYC bar is trying it with Knicks promotion
Kalshi is relying on Wednesday's Knicks game and a New York City bar to show off its hedging-for-the-masses strategy. A local New York City bar on the Upper East Side is promising customers that if the Knicks win its first game against the Spurs, it will pay for everyone's tab. It's able to execute that bold promise because of hedging.
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His toxic Henry Nowak intervention fits a pattern. Vance has hard-right views, a disdain for European society – and he may yet become presidentImmigration is falling in Britain. It’s falling so fast and so hard – net migration to the UK nearly halved between 2024 and 2025 – that before long we could conceivably be a shrinking population, with more people leaving the country than coming here.