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Decoding Chromosome Radiosensitivity in G0-Phase PBMCs: Genomic Determinants, Age, Sex effects, and Implications in Radiation Dose Assessment

Low-dose ionizing radiation from natural and anthropogenic sources is typically not of significant concern under normal conditions. However, in case of radiological incidents, it becomes an important environmental hazard, raising concern for public health and necessitating reliable biological indicators of exposure. Chromosomal aberrations are most reliable markers of radiation exposure and are more or less universally assessed in metaphases.

bioRxiv 8d ago