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Brind'Amour mum on G4 changes, including goalie
LAS VEGAS -- Carolina Hurricanes coach Rod Brind'Amour said he doesn't "anticipate a lot of changes" to his Game 4 lineup after his team fell behind 2-1 in its Stanley Cup Final series against the Vegas Golden Knights. Does that mean goalie Freddie Andersen has the crease back after getting pulled in the third period of Carolina's Game 3 loss Saturday? "We'll make all decisions after we practice tomorrow, see how he's feeling," Brind'Amour said Sunday, the first of two off days between games.
G quadruplex DNA facilitates a pervasive path to homologous recombination
Homologous recombination (HR) requires efficient homology search and strand invasion, yet how homologous templates are identified within the nucleus remains unclear. Here, we identify G-quadruplex (G4) DNA structures as pervasive effectors of template strand invasion and uncover the G4 helicase DHX36 as a potent suppressor of this process. DHX36 loss stabilizes G4s, enhances HR, and accelerates repair of replication-associated DNA breaks.
A Crossed Laser Phase Plate for CryoEM
The laser phase plate (LPP) enables phase-contrast imaging in cryogenic electron microscopy (cryoEM), enhancing image contrast without compromising high-resolution information. Here we report the implementation of a crossed laser phase plate (xLPP) comprising two optical cavities oriented orthogonally, installed in a ThermoFisher Scientific Krios G4 microscope equipped with a newly designed transfer lens module. We demonstrate the expected, strong contrast enhancement and stable, additive...
Overlooked DNA structures help organize the genome
Overlooked DNA structures help organize the genome Lisa Lock Scientific Editor Robert Egan Associate Editor Northwestern Medicine scientists have discovered that little-studied DNA structures play a central role in organizing the human genome and controlling gene activity, according to a new study published in the Proceedings of the National Academy of Sciences. The study revealed that G-quadruplexes (G4s)—four-stranded DNA structures—directly interact with a key genome-organizing protein...
Macsurf, "modern" web browser for macOS 9
The modern web, on a 25-year-old Mac. MacSurf is a web browser for Classic Mac OS 9 PowerPC. CSS3, ES5 JavaScript, PNGs with alpha, running on a G3 iMac.
Toward Pre-Deployment Assurance for Enterprise AI Agents: Ontology-Grounded Simulation and Trust Certification
Announce Type: new Abstract: Pre-deployment verification of enterprise artificial intelligence (AI) agents remains a critical gap between large language model (LLM) capability benchmarking and production deployment. Post-deployment monitoring, human-in-the-loop controls, and prompt-level guardrails offer limited assurance once an agent is operating in production. We propose an ontology-grounded verification framework combining three components: an Agent Operational Envelope formalizing the...
Norway Chess: Praggnanandhaa takes revenge on Gukesh; title race goes to final day
These were the names of the opponents Rameshbabu Praggnanandhaa faced, or, more accurately, outsmarted, over his last three rounds. Three consecutive wins, each in the classical format, have put the 20-year-old right in the running for this year's Norway Chess crown in the open section. While the women's section saw Bibisara Assaubayeva draw her Round 9 classical game against Anna Muzychuk to wrap up the Norway Chess Women's title on Thursday in Oslo, the open section remains wide open.
Sky spectacle: where to see the northern lights in Germany this weekend
According to the US weather agency NOAA, solar storms are forecast for the weekend that could produce vivid auroras, or northern lights, across North America and Canada. In the United States, the weather monitoring agency has announced that the northern lights could be visible in the northern United States and Canada, as strong geomagnetic storms are expected. These could also light up the skies over Germany, especially in the north and along the coasts, during the night of 5 to 6 June.
Jef Raskin, the Visionary Behind the Mac (2013)
Jef Raskin founded the Macintosh project at Apple, which led to the development of the Apple Mac and the popularisation of the graphical user-interface. He was Apple employee #31 and left the Macintosh team in mid-1981 after Steve Jobs took over the project. Jason Walsh: Before the Mac you were a professor of music.