G4s
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Overlooked DNA structures help organize the genome
Overlooked DNA structures help organize the genome Lisa Lock Scientific Editor Robert Egan Associate Editor Northwestern Medicine scientists have discovered that little-studied DNA structures play a central role in organizing the human genome and controlling gene activity, according to a new study published in the Proceedings of the National Academy of Sciences. The study revealed that G-quadruplexes (G4s)—four-stranded DNA structures—directly interact with a key genome-organizing protein...
G quadruplex DNA facilitates a pervasive path to homologous recombination
Homologous recombination (HR) requires efficient homology search and strand invasion, yet how homologous templates are identified within the nucleus remains unclear. Here, we identify G-quadruplex (G4) DNA structures as pervasive effectors of template strand invasion and uncover the G4 helicase DHX36 as a potent suppressor of this process. DHX36 loss stabilizes G4s, enhances HR, and accelerates repair of replication-associated DNA breaks.
Mongols bikie escapes custody after scaling court dock, dashing past security
Police manhunt under way in Darwin for 44yo bikie Brandt Graham after escape from court custody Fri 5 Jun 2026 at 3:31pm A manhunt is under way in Darwin for a 44-year-old bikie after he scaled an enclosed courthouse dock and escaped from custody today. Northern Territory Police said Brandt Graham absconded from security guards at the Darwin Local Court at 9:50am. Court documents obtained by the ABC reveal Mr Graham is a patched member of the Mongols Motorcycle Club, regarded by police as an...