GAPVD1
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Related Articles from SNS
GAPVD1 regulates CSNK1D-dependent PER2 FASP phosphorylation
The mammalian circadian clock relies on precisely timed transcriptional and post-translational events to generate ~24-hour rhythms. A key post-translational mechanism is phosphorylation of PER2 by CSNK1D, governed by a phosphoswitch that integrates stabilizing and destabilizing phosphorylation marks at the FASP and Degron sites to control PER2 stability and circadian period. Here, a novel role for the PER complex protein GAPVD1 in regulating CSNK1D-mediated FASP site phosphorylation is revealed.