GLOF
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Related Articles from SNS
GLOF: A large-scale expert-curated benchmark dataset of gain-of-function and loss-of-function missense variants
Distinguishing loss-of-function (LOF) from gain-of-function (GOF) effects of missense variants is fundamental to understanding disease mechanisms and guiding therapeutic strategy, yet no large-scale, expert-curated benchmark has been publicly available for this task. Here we present GLOF (Gain and Loss Of Function), a dataset of 112,399 missense variants across 2,809 human genes, each classified as LOF, GOF, or neutral by board-certified clinical geneticists following ACMG guidelines....
An Adaptive Log-Laguerre Spectral Method for the Radial Dirac Equation: Resolving Asymptotic Decay and Core Singularities in Atomic Calculations
arXiv:2604.11063v2 Announce Type: replace Abstract: The high-precision solution of the radial Dirac equation is fundamental to relativistic quantum chemistry, essential for reliable pseudopotential generation and all-electron electronic structure methods. Capturing both the non-polynomial singularities at the origin and the state-dependent asymptotic decay on semi-infinite domains presents a significant computational challenge. In this work, we propose the Adaptive Log-Laguerre Spectral...