GPCR
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Related Articles from SNS
Temporal coding expands the bandwidth of GPCR-mediated neuromodulation
The advent of modern transcriptomic approaches has revealed a breadth of neuromodulatory G protein-coupled receptor (GPCR) co-expression far exceeding what was previously thought. This raises a fundamental question about neuromodulatory system architecture because there is a much smaller number of available G protein transducers. Does this impose an information 'bottleneck', or can a single transducer pathway distinguish the effects of different neuromodulators?
S-nitrosylation of protein kinase A is required for its activation by GPCRs
Stimulation of many G protein-coupled receptors (GPCRs) increases cyclic adenosine monophosphate (cAMP) and nitric oxide (NO). While cAMP-dependent activation of protein kinase A (PKA) is a central regulatory mechanism, a parallel role for NO in GPCR transduction has not been established. Here we show that upon stimulation of multiple GPCRs in heart, brain, and fat, the regulatory subunits of PKA undergo enzymatic S-nitrosylation by SNO-CoA-assisted nitrosylase (SCAN).