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Transcriptomic and proteomic responses to gas vesicle collapse in native and engineered bacterial systems
Gas vesicles (GVs) are air-filled protein nanostructures produced by microbes to regulate buoyancy and have emerged as powerful tools in biomedical imaging, particularly as acoustic reporter genes. Their mechanically robust shells enclose a stable air compartment, which collapses irreversibly when subjected to sufficient hydrostatic or acoustic pressure, leaving behind large protein sheets. This collapse phenomenon underlies key applications such as differential imaging and controlled...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
8 workers killed, several critical in Vizag Steel Plant accident
Visakhapatnam: At least eight workers were killed and several suffered critical burn injuries after an explosion triggered a massive spill of superheated liquid metal at the Rashtriya Ispat Nigam Limited’s Visakhapatnam Steel Plant in Andhra Pradesh on Monday afternoon. According to preliminary information, a ladle carrying liquid steel at temperatures of around 1,600°C suddenly exploded in the continuous casting department of the plant’s steel melting facility. The explosion caused tonnes...