Galectin
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Related Articles from SNS
Galectin-3 recruitment at the Mycobacterium tuberculosis-containing phagosome is critical in macrophage but dispensable in epithelial cells
Mycobacterium tuberculosis (Mtb) virulence relies in part on its ability to induce phagosomal membrane rupture, enabling bacterial access to the host cell cytosol. This process is largely mediated by the ESX{middle dot}1 secretion system, which is present in Mtb but absent from the vaccine strain BCG. Galectin{middle dot}3 (Gal3), a {beta}{middle dot}galactoside{middle dot}binding lectin, is recruited to damaged endomembranes and functions as a cytosolic sensor of membrane disruption.
Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo
The neonatal cochlear epithelium harbors regenerative capacity, attributable to the transient greater epithelial ridge (GER). After injury, GER cells re-enter the cell cycle, migrate into the damaged organ of Corti, and differentiate into sensory or supporting cells in vivo; in culture, they proliferate to form inner ear organoids. The mechanisms underlying this competence remain unclear.