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Credit cards aren’t evil – if you know how to use them the right way | Gene Marks
Using a credit card is no different than having a drink or two at dinner or a Big Mac once in a while. It’s fine, just don’t overdo itThe percentage of credit card balances that were at least 90 days delinquent rose to 13.12% in the first quarter of this year, according to data released in May by the Federal Reserve Bank of New York. As the Wall Street Journal reported: “That’s the highest level in 15 years, and the most since the period following the 2008 financial crisis.”
Gap junctions in the alimentary tract regulate reproductive span in C. elegans
Aging does not occur uniformly throughout an organism but is instead differentially regulated across distinct physiological systems. In particular, reproductive aging is often temporally distinct from somatic aging and exhibits species-specific trajectories, suggesting that different physiological functions may age independently. Here we show that mutation of inx-20, an innexin family gene encoding a gap junction component, markedly extends reproductive span, with only a minor increase in...
First whole-genome sequence of a Greenland shark holds clues to their extreme longevity
First whole-genome sequence of a Greenland shark holds clues to their extreme longevity A genomic study of Greenland sharks, thought to be the longest-lived vertebrates on the planet, is hinting at the secrets to their epic lifespan and cancer resistance. The first-ever whole-genome sequence of a Greenland shark has revealed genetic clues to how the animals avoid cancer and live for hundreds of years. The work may pave the way to a better understanding of age-related diseases in humans.
Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21
Correct neural progenitor cell (NPC) fate specification is essential to produce the full complement of neurons and glia needed for proper brain structure and function. Neurodevelopmental disorders, including the autosomal aneuploidy Down syndrome (DS), or Trisomy 21 (T21), are frequently associated with impaired cell fate decisions which ultimately drive differences in overall brain size and cell type composition through unknown mechanisms. To uncover mechanisms driving altered NPC fate in...
High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy response
Tumor-specific exhausted CD8 T cells (Tex) adopt diverse phenotypes across human cancers, but the drivers of this heterogeneity remain poorly understood. Using flow cytometry and single-cell RNA and T cell receptor (TCR) sequencing of 106,667 tumor-infiltrating CD8 T cells from head and neck squamous cell carcinoma (HNSCC) tumors, we identified and validated three Tex subsets, each with distinct clonotypes: (1) Tex-Conv, expressing conventional exhaustion genes; (2) Tex-CCR6, distinguished...
Scientists discover the master clock that controls biological growth and development
Scientists discover the master clock that controls biological growth and development - Date: - June 4, 2026 - Source: - Cold Spring Harbor Laboratory - Summary: - A newly discovered genetic clock acts as the master timekeeper for development, orchestrating crucial bursts of gene activity throughout a worm’s growth. When the clock is disrupted, development stops, offering fresh clues about how growth-related disorders may arise. - Share: Imagine a train sitting at a station.
Active Nuclear Shuttling Enables Efficient Virus-Free CAR Gene Integration Using Ready-to-Use Lipid Nanoparticles
Non-viral engineering of chimeric antigen receptor T (CAR -T) cells is highly desirable to overcome the cost, safety, and scalability limitations associated with viral vectors and electroporation. However, efficient nuclear delivery and stable genomic integration of DNA in primary human T cells remain major challenges. Here, we established a virus-free CAR-T manufacturing platform using lipid nanoparticles (LNPs) combined with a nuclear localization signal (NLS) shuttle strategy.
Read an extract from The Selfish Gene by Richard Dawkins
Dive into the opening of The Selfish Gene's first chapter 'Why are people?', the New Scientist Book Club’s read for June to mark 50 years since the popular science classic was first published
Recovered wild maize gene boosts crop protein without yield loss
Recovered wild maize gene boosts crop protein without yield loss Gaby Clark Scientific Editor Robert Egan Associate Editor Maize (Zea mays L.) plays an important role in global food security. During 9,000 years of maize domestication and breeding, however, protein content was not a major breeding target. Consequently, many beneficial gene variants associated with higher protein content were gradually lost from cultivated maize.
Sex and Alternative Splicing in Disease: a meta-analytic approach to identify interactions
How cell type, sex and disease interact and affect gene expression and splicing is an important, but complicated question. Visualizing and testing specific hypotheses around these complex interactions is an important first step to identifying molecular components underpinning complex disease. Using a meta-analytical framework, we develop an analytical path for identifying testable molecular hypotheses of complex interactions between splicing, sex, disease and cell type.