Genetic Information Processing Complexity
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Genetic Information Processing Complexity as a Determinant of Virus Diversity
Viruses exhibit diverse genome architectures and replication strategies that shape their evolutionary trajectories and taxonomic diversification. Here, we test whether the complexity of viral genetic information processing predicts large-scale patterns of viral diversity. We define a propagation index that quantifies a minimal number of steps required for viral genome expression and replication across the Baltimore classes.
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
In a first, scientists translated an entire viral genome so a quantum computer could read and analyze it
In a first, scientists translated an entire viral genome so a quantum computer could read and analyze it Scientists have uploaded a viral genome to a quantum computer, marking an important step for the future of quantum-enabled advancements in biology. Scientists say they have uploaded a real genome to a quantum computer for the first time, marking an important step in applying the emerging technology to biology. The researchers encoded the entire genome of the hepatitis D virus (HDV) onto a...
Plants could be used to grow medicines in space, study shows
Plants could be used to grow medicines in space, study shows Lisa Lock Scientific Editor Robert Egan Associate Editor Astronauts on long space missions may one day use plants to produce fresh stocks of medicines on demand, thanks to new research by engineers at the University of California San Diego. The team developed a simple method to grow and repeatedly harvest pharmaceuticals from plants under space-like conditions, without destroying the plants or generating large amounts of waste. The...
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.
Complex-phase stochastic modeling of mitochondrial heteroplasmy
Mitochondrial heteroplasmy the coexistence of both wild-type and mutant copies of mitochondrial DNA ( mtDNA ) within a cell is a key factor in the pathogenesis of mitochondrial diseases. Classical approaches, which rely solely on the scalar fraction of mutant DNA, fail to fully account for threshold effects, the stochastic nature of heteroplasmy dynamics , and tissue specificity. The aim of the work is to construct a complex stochastic model of heteroplasmy dynamics , which for the first...
Scientists mapped every neural connection in a fruit fly and found a surprise
Scientists mapped every neural connection in a fruit fly and found a surprise Scientists have completed the first full brain-to-body wiring map of a fruit fly, revealing that behavior may be driven more by local neural teamwork than by a central brain command center. - Date: - June 10, 2026 - Source: - Harvard Medical School - Summary: - A groundbreaking new connectome maps every neural connection in an adult fruit fly’s central nervous system, creating an unprecedented view of how the brain...
Iberian DNA remained largely unchanged for six centuries before Roman influence, study finds
Iberian DNA remained largely unchanged for six centuries before Roman influence, study finds Lisa Lock Scientific Editor Robert Egan Associate Editor A study led by a UAB research team of Biological Anthropology has analyzed the genome of 54 newborns with the aim of tracking the genetic history of their culture since it developed in the Early Iron Age until the start of the Roman period, some 2,700 to 2,100 years ago. Despite being in contact with other Mediterranean cultures, the genetic...
Species of Brazilian moths described in honor of Orixás, foundational deities of Afro-Brazilian religions
Species of Brazilian moths described in honor of Orixás, foundational deities of Afro-Brazilian religions Stephanie Baum Scientific Editor Robert Egan Associate Editor A species of moth that was first described in 1818 was believed to be a single species. However, it has since been discovered that it is actually a complex of species, eight of which are found in Brazil. These findings are the result of a study that integrated molecular techniques, morphological data, and the identification of...