HCM
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Physical Plausibility Reasoning via HCM-GRPO: Empowering Compact Model for Superior Performance
arXiv:2511.10055v2 Announce Type: replace Abstract: The performance of image generation has been significantly improved in recent years. However, the study of image screening is rare, and its performance with Multimodal Large Language Models (MLLMs) is unsatisfactory due to the lack of data and the weak physical plausibility reasoning ability in MLLMs. In this work, we propose a complete solution to address these problems in terms of data and methodology.
Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance
Aims Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic heart disorder, characterized by significant phenotypic variability even among individuals with identical MYH7 mutations. This study aims to elucidate factors contributing to this variability and identify drivers of phenotype penetrance. We compared the baseline phenotypes of a highly penetrant MYH7 H251N mutation and the variably penetrant MYH7 G256E mutation and investigated the impact of adding beta-adrenergic...
China’s nuclear expansion shocks world! Is India falling behind?
Deep in the remote deserts of Xinjiang, China is quietly building what analysts believe could become one of the most sophisticated nuclear support networks in the world. Newly reviewed satellite images examined by Reuters reveal more than 80 launch pads and three large octagon-shaped military facilities spread across thousands of square kilometres near the Hami nuclear missile silo field. Major Gaurav Arya explains that the construction is aimed at enhancing China's "land-based second-strike...
The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motor
{beta}-cardiac myosin is the primary motor protein in the human heart responsible for force generation by converting chemical energy from ATP hydrolysis to mechanical work. It binds actin, produces force through its powerstroke, and releases actin, and must complete this cycle several times a second within each heartbeat. Like other muscle myosins, cardiac myosin has a low duty ratio of ~5%, the fraction of time in the actin-bound force-producing state.