HCV
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Related Articles from SNS
The intertwined fate: exploring the hepatitis C virus/Nrf1 crosstalk
Despite advances in knowledge and medicine, hepatitis C virus (HCV) infection remains a global challenge. The viral life cycle heavily depends on lipid metabolism; therefore, HCV infection is associated with profound changes in host lipid homeostasis. The transcription factor nuclear factor erythroid 2 related factor-1 (Nrf1) is one of the regulators maintaining this homeostasis.
Modeling in vitro cell-to-cell spread of hepatitis C viral infection using an agent-based approach
Mechanisms that lead to viral chronicity are poorly understood, but cell-to-cell spread has been implicated in the establishment of chronic infections. We previously developed mathematical models to explore the nature of hepatitis C virus (HCV) cell-to-cell spread in vitro and quantified the effect of inhibiting individual host factors involved. However, the previous models were not designed to (i) address cell proliferation, (ii) account for differences in cell size, and (iii) did not...