HICAT
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Related Articles from SNS
From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT
Pathologist-annotated tissue regions provide a fundamental reference for examining spatial omics data, yet such annotations are available for a limited number of samples due to the substantial manual effort required. Moreover, these annotations are derived from morphology within individual histology images, which can overlook molecularly defined regions and obscure intra-sample heterogeneity. To address these limitations, we present HiCAT, a machine-learning framework that automatically...
Adaptive Causal Alignment for High-Confidence Adversarial Training
new Abstract: Inverse adversarial training leverages high-confidence predictions to stabilize robust learning, yet we uncover a critical paradox: high confidence often stems from overfitting to non-causal background correlations rather than intrinsic object semantics. Our investigation reveals that visual context functions as a dual-natured signal, serving as either a necessary supportive prior or a spurious confounder. This insight renders existing blind suppression strategies flawed, as...