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Cryo-EM provides insight into how the Staphylococcus aureus IsdH receptor removes hemin from the hemoglobin:haptoglobin complex

Staphylococcus aureus extracts hemin from human hemoglobin (Hb) to overcome host-imposed iron limitation. How it recovers Hb-bound hemin from the hemoglobin:haptoglobin (Hb:Hp) complex, the major circulating form of Hb outside red blood cells, remains unclear. Here we use cryo-electron microscopy, biophysical measurements, and solution kinetics to define how the S. aureus IsdH surface receptor extracts hemin from Hb:Hp.

bioRxiv 2d ago

Coordinated neural, metabolic and muscular transcriptomic signatures associated with mite-biting behavior in honeybees (Apis mellifera L.)

Biting behavior is an important natural defense mechanism in honeybees (Apis mellifera) against Varroa destructor. Significant variation in this behavior exists across genetic lines of honeybees, with certain colonies exhibiting higher mite-biting activity than others. Selective breeding for enhanced biting behavior provides a promising strategy for sustainable mite control and colony resilience.

bioRxiv 10d ago

Basis construction for polynomial spline spaces over arbitrary T-meshes

arXiv:2508.12950v3 Announce Type: replace Abstract : This paper presents the first method for constructing bases for polynomial spline spaces over an arbitrary T-meshes (PT-splines for short). We construct spline basis functions for an arbitrary T-mesh by first converting the T-mesh into a diagonalizable one via edge extension, ensuring a stable dimension of the spline space.

arXiv CS 2d ago

An Efficient Parity-Blocked Method for Band-Structure Computation of 3D Anisotropic Phononic Crystals

new Abstract: Band-structure calculations for three-dimensional anisotropic phononic crystals require the repeated solution of large elastic generalized eigenvalue problems along Bloch paths. In standard staggered-grid discretizations, anisotropic coupling may involve derivative components located at incompatible grid positions, so additional interpolation or averaging closures are often introduced. This paper proposes a parity-blocked rotated staggered discretization based on four...

arXiv CS 7d ago