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Obstructive Sleep Apnea Syndrome Disrupts Glymphatic-Related Physiological Brain Pulsations

Background: Obstructive sleep apnea (OSA) affects over one billion people and increases neurodegenerative risk. Brain vasomotor, respiratory, and cardiac pulsations are thought to drive glymphatic clearance during sleep, yet OSA's effect on these pulsations remains poorly understood. Methods: We studied 20 healthy controls (HC; 39.7{+/-}8.0 y) and 12 patients with OSA (PWOSA; 53.0{+/-}11.0 y) using a four wavelength (690-980 nm) functional near-infrared spectroscopy (fNIRS) measuring...

bioRxiv 5d ago