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Efficient ageing: Simulated lesion of the structural connectome reveals optimised decline in the healthy ageing brain

Healthy ageing is associated with widespread white-matter change and altered connectome organisation, yet the link between local microstructural decline and whole-brain network communication remains unclear. Here we combined tract-based spatial statistics (TBSS) with probabilistic tractography and graph analysis to quantify the connectome-level consequences of age-sensitive white-matter hotspots. In two independent diffusion MRI datasets of healthy young and older adults (n = 144 total;...

bioRxiv 8d ago

Vitality capacity preservation through lifelong aerobic exercise: a pathway to healthy ageing

Background The distinction between healthy and pathological ageing has led to the concept of vitality capacity (VC), which can be understood as the body physiological reserve. An individual VC can be estimated using 12 biomarkers spread across 3 domains: immune and stress response, energy and metabolism and neuromuscular function. Vitality capacity may be preserved by lifelong physical activity.

bioRxiv 6d ago

Queen Elizabeth II's daily breakfast that may have been secret to living to 96

Queen Elizabeth II's daily breakfast that may have been secret to living to 96 The late monarch's first meal of the day was surprisingly simple, but experts say it contained nutrients linked to healthy ageing Queen Elizabeth II enjoyed some of the finest food available during her 70-year reign, but one meal she reportedly kept remarkably simple was breakfast. The late monarch, who became Britain's longest-serving sovereign before her death aged 96 in September 2022, is understood to have...

Daily Mirror 5h ago

The forgotten organ that could predict how long you live

The forgotten organ that could predict how long you live A forgotten immune organ may be one of the strongest hidden predictors of longevity, disease risk, and cancer treatment success. - Date: - June 1, 2026 - Source: - Mass General Brigham - Summary: - A long-overlooked organ may hold surprising clues to healthy aging and cancer survival.

Science Daily 9d ago

Has sparkling water come of age?

We pop open a selection of fun but healthy fizzy flavoured waters that should satisfy even the fussiest princessI am not a princess about many things, but there has to be sparkling water in the house. Refreshing, enlivening and occasionally hangover-clearing, it is an essential. Thankfully, my husband is aligned with me (it would never have worked with someone who answered: “Tap’s fine”, when offered water in a restaurant).I’m not fussy about my fizzy, though – SodaStreamed tap is fine – but...

The Guardian UK 6d ago

The biggest collagen study yet reveals what actually works

The biggest collagen study yet reveals what actually works A massive review of collagen research found that the supplements can improve skin elasticity and hydration while helping reduce osteoarthritis pain and stiffness. - Date: - June 5, 2026 - Source: - Anglia Ruskin University - Summary: - A major review of nearly 8,000 participants found that collagen supplements can improve skin health and ease osteoarthritis symptoms, especially when taken consistently over longer periods.

Science Daily 5d ago

Longevity medicine: the scientific challenge of adding life and energy to our years

As Spain ages and becomes one of the countries with the highest life expectancy, doctors and new research are driving preventive and longevity medicine, seeking to be democratised and free of fraud so that people can enjoy their final years in good health. Population ageing is one of the major demographic and health challenges of our time. Spain is at the forefront of global longevity, with average life expectancy already reaching 84 years.

Euronews 2d ago

Just 90 minutes of one regular exercise per week could lower early death risk, study finds

Just 90 minutes of one regular exercise per week could lower early death risk, study finds A major long-term study has found that one particular exercise is linked to lower mortality rates and could make a significant difference to your health New research reveals that just 90 minutes to two hours of weight training weekly could substantially cut the risk of premature death, a major long-term study has found. The findings, published in the British Journal of Sports Medicine, show that...

Daily Mirror 7d ago

A prognostic human brain network for diffuse midline glioma

Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.

Nature 17h ago

Comparison of Automated White Matter Lesion Segmentation Approaches for Use in Large, Multi-Site Data Analyses in Parkinson's Disease

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder. PD currently lacks effective disease-modifying treatments, likely due to its diverse clinical features and underlying neuropathology. The vascular role in PD is emerging, with vascular mechanisms increasingly implicated, yet the literature remains conflicted, motivating large-data analyses with greater statistical power.

bioRxiv 11d ago