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Related Articles from SNS
Periplasmic detoxification of urate hydroperoxide underpins E. coli survival in the inflamed gut
Uric acid, the final product of purine metabolism in humans, accumulates in blood and tissues at relatively high concentrations as humans lack the enzyme uricase. Under inflammatory conditions, uric acid can be oxidised to yield reactive intermediates. In activated neutrophils, myeloperoxidase (MPO) catalyses the oxidation of uric acid by hydrogen peroxide, leading to the formation of urate hydroperoxide (UH).