HuR
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Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Judge with intimate ties to Dem Party's key Russia Hoax players behind latest anti-Trump decision
The judge who ordered President Donald Trump's name removed from the Kennedy Center is married to an attorney who has represented a former anti-Trump FBI lawyer, served as counsel to the House Jan. 6 committee and currently represents former President Joe Biden — relationships that Trump blasted as clear conflicts of interest following the ruling. Trump claimed in a heated Truth Social post that U.S. District Court of D.C. Judge Christopher Cooper's wife, Amy Jeffress, a former Obama-era...
The Lag Between an Iran Deal and Lower Oil Prices
This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here.For months, Donald Trump has been desperate for Iran to loosen its grip on the Strait of Hormuz. Now he says it’s happening; a deal to reopen the waterway “has been largely negotiated,” per a Truth Social post on Saturday.
Judge with intimate ties to Dem Party's key Russia Hoax players behind latest anti-Trump decision
The judge who ordered President Donald Trump's name removed from the Kennedy Center is married to an attorney who has represented a former anti-Trump FBI lawyer, served as counsel to the House Jan. 6 committee and currently represents former President Joe Biden — relationships that Trump blasted as clear conflicts of interest following the ruling. Trump claimed in a heated Truth Social post that U.S. District Court of D.C. Judge Christopher Cooper's wife, Amy Jeffress, a former Obama-era...
Former Biden aides 'don't believe' Jill Biden, are angry over ex-first lady's debate comments, reporter says
Former first lady Jill Biden is now the target of ire among former Biden administration officials on Thursday for her recent comments expressing the shock she said she had while watching her husband's now-infamous debate performance.Alex Thompson, the Axios reporter who co-wrote "Original Sin," the book released last year that delved into former President Joe Biden's cognitive decline scandal, said he's been flooded with reactions from members of Biden's orbit after Jill Biden began speaking...