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California’s conservative Huntington Beach could get a gay, Democratic congressman
Robert Garcia became the lead contender in Tuesday’s primaries for congressional district 42 after redistrictingThe conservative California community of Huntington Beach, known for banning the Pride flag from city property and fighting the state over pandemic and housing policy, could soon be represented by a gay, Democratic congressman. Robert Garcia, an incumbent two-term Democratic LGBTQ+ congressman, immigrant and Donald Trump critic, is considered the leading contender in Tuesday’s...
Explaining Unsupervised Disease Staging in Huntington's Disease: Insights into Model Representations and Clusters
arXiv:2606.07135v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder that affects motor, cognitive, and behavioral functions, where accurate characterization of disease progression remains essential to improve patient outcome and quality of life. Unsupervised machine learning (ML) approaches have demonstrated the ability to uncover disease progression trajectories and meaningful latent stages from longitudinal data; however, their limited...
The Happy Pod: Hope for people with Huntington's disease
For the first time ever, a successful treatment has been found for the devastating brain disease, Huntington's. The inherited condition, which resembles a combination of dementia, Parkinson's and motor neurone disease, affects hundreds of thousands of people in the US and Europe. The scientists who developed the new gene therapy, and people who have the disease, say its a huge breakthrough that could give people a better quality of life for decades.
A Machine Learning-Based Framework for Discovering Huntington's Disease Stages: Integrating Graph Representation Learning and clustering to Uncover Progression Dynamics in Longitudinal Enroll-HD Dataset
arXiv:2606.06196v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive brain disorder that gradually affects movement, cognitive function, and behavior. Identifying the stage of the disease accurately and consistently is important for understanding its course, grouping patients, personalized care, and discovering treatment. Existing clinical staging frameworks rely primarily on predefined clinical measurement thresholds and clinical expert decisions, yet these discrete...
Macrocyclic Peptide Tools for Huntingtin-bound HAP40
Huntington's disease is a fatal neurodegenerative disorder caused by expansion of a cytosine-adenosine-guanine repeat in exon 1 of the Huntingtin (HTT) gene, resulting in a polyglutamine-expanded HTT protein. Although the genetic cause of Huntington's is well defined, the molecular functions of HTT and the mechanisms linking polyglutamine expansion to neurodegeneration remain incompletely understood. Huntingtin Associated Protein 40 kDa (HAP40) is a key HTT interaction partner that forms a...
Hilton, Becerra, in the lead with votes still being counted in battle for California governor
HUNTINGTON BEACH, CA - Republican Steve Hilton and Democrat Xavier Becerra were leading in unofficial early returns Wednesday morning and appeared positioned to advance to the November California gubernatorial election in the race to succeed term-limited Democratic Gov. Gavin Newsom in steering the nation's most populous state and one of the world’s largest economies. Hilton, a one-time British political strategist turned American conservative commentator and former Fox News Channel host who...
Hilton, Becerra, in the lead with votes still being counted in battle for California governor
HUNTINGTON BEACH, CA - Republican Steve Hilton and Democrat Xavier Becerra were leading in unofficial early returns Wednesday morning and appeared positioned to advance to the November California gubernatorial election in the race to succeed term-limited Democratic Gov. Gavin Newsom in steering the nation's most populous state and one of the world’s largest economies. Hilton, a one-time British political strategist turned American conservative commentator and former Fox News Channel host who...
An Ohio Valley 100k-Watt FM Signal Is Severed in Broad Daylight – Radio World
Evan Adkins, director of engineering, called Mike Kirtner, the president of Kindred Communications, last Thursday just prior to lunchtime. “Are you sitting down?” Adkins asked Kirtner after he answered the phone.
Mom interrupts mayor’s speech at high school graduation to accuse him of wrongdoing with her daughter
Mom interrupts mayor’s speech at high school graduation to accuse him of wrongdoing with her daughter The mayor agreed to speak at the Class of 2026 ceremony but declined to distribute diplomas after the student’s mother requested he skip the graduation - Bookmark - CommentsGo to comments Massachusetts State Police are investigating a formal complaint against Brockton Mayor Moises Rodrigues following an incident where a mother disrupted his speech at Brockton High School’s graduation...
Inside Wealth: Trump's 'big beautiful bill' has a 'double taxation' trap for top earners, tax lawyers say
A version of this article first appeared in CNBC's Inside Wealth newsletter with Robert Frank, a weekly guide to the high-net-worth investor and consumer. Sign up to receive future editions, straight to your inbox. The "one big beautiful bill" came with many tax benefits for top earners, despite limiting how much they can deduct.