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In Vitro Efficacy of Paclitaxel-loaded PLGA Nanoformulations for Lung Cancer Treatment Demonstrated by Label-free Multiphoton-Fluorescence Lifetime Imaging Microscopy
Lung cancer remains the leading cause of cancer-related mortality, and despite its limited efficacy, and low specificity, chemotherapy is still commonly used as a first-line treatment. Herein, we prepare and characterize poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) for the use as a non-targeted nanocarrier drug delivery system for the chemotherapeutic drug, paclitaxel (PTX). Drug loading capability, mono-dispersity, zeta potential, morphology, and drug release profile were...
Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity
Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5' [->] 3' alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA that can be packaged into infectious virus.