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Related Articles from SNS
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Blood test can predict lung cancer 5 years before diagnosis
Scientists have identified warning signals in the blood that can predict lung cancer more than five years before the disease is diagnosed, a breakthrough that could help tackle one of India’s deadliest cancers, where most patients are detected only at an advanced stage. The findings are particularly relevant for India, where lung cancer cases are projected to rise from about 63,700 in 2015 to more than 81,000 by 2025 and nearly 80-85% of patients are diagnosed at an advanced stage. Published...