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Chronic cocaine exposure negatively impacts Long-COVID-like outcomes produced by the SARS-CoV-2 spike protein in the rat
Acute COVID-19 outcomes are exacerbated by substance use, however, the impact of substance use on Long-COVID is unknown. Here, we investigated the impact of chronic cocaine administration on spike-induced Long-COVID-like outcomes in the rat. Rats received intermittent chronic cocaine administration and a single intravenous injection of the SARS-CoV-2 spike protein.
Choriodecidual Ureaplasma parvum infection induces fetal lung inflammation prior to intra-amniotic infection in a nonhuman primate model
Preterm birth before 28 weeks remains a leading cause of neonatal mortality and long-term morbidity. Intrauterine infection-driven chorioamnionitis is strongly associated with preterm labor, fetal inflammatory response syndrome, and neonatal lung disease. Ureaplasma species are among the most common organisms isolated in chorioamnionitis and are frequently detected in the placenta, amniotic fluid, and respiratory tract of preterm infants.
p38 dependent IL-33 responses define a conserved inflammatory programme in mast cells
Interleukin-33 (IL-33) is a key cytokine in mast cell mediated immunity, promoting inflammatory cytokine production without inducing degranulation. Here, we compared IL-33 induced proteomic responses across three mast cell culture systems, Foetal Liver derived Mast Cells (FLMCs), Bone Marrow derived Mast Cells (BMMCs), and Peritoneal Mast Cells (PMCs), using quantitative data-independent acquisition mass spectrometry. Although baseline proteomes were largely conserved across all mast cell...
Tools to fight hantavirus show promise despite limited funding. Now researchers hope to continue
Tools to fight hantavirus show promise despite limited funding. Now researchers hope to continue Andrew Zinin Lead Editor When a rare but deadly rodent-borne virus struck passengers on a cruise ship and seemed to be spreading, there were no treatments for those who fell ill and no vaccines to protect others. That was the case even though it wasn't a novel germ that the world had never seen before, like the virus that caused the coronavirus pandemic.
Neutrophil-Derived Oncostatin M Contributes to Endothelial Cell Dysfunction During Treponema denticola interaction
Periodontitis (PD) is a common chronic inflammatory condition and a risk factor for cardiovascular diseases (CVD), yet underlying linking mechanisms remain unclear. The cytokine Oncostain M (OSM) is elevated in both PD and CVD and has emerged as a potential mediator linking oral inflammation to vascular dysfunction. Neutrophils represent a prominent source of OSM during PD and OSM production is elevated by the periodontal pathobiont Treponema denticola (Td).
Organ on chip model of respiratory vascular interactions under COPD relevant oxidative stress
Oxidative stress-induced airway injury contributes to chronic obstructive pulmonary disease (COPD). Cardiovascular complications increase COPD morbidity and mortality, but mechanistic links between airway injury and vascular dysfunction remain unclear, largely due to limitations of in vitro models that fail to replicate the multicellular lung environment. We developed REVAS, a modular organ-on-chip platform to study human respiratory-vascular cell-cell interactions at baseline and under...
Nuclear confinement from matrix stiffness drives epigenomic reprogramming of gingival fibroblasts
Periodontal disease is characterized by progressive degradation of the gingival extracellular matrix and loss of the physical confinement it imposes on resident stromal cells. In human periodontal tissue, ECM collagen integrity is inversely correlated with facultative nuclear histone acetylation in stromal cells. We hypothesized that matrix stiffness directly coordinates an epigenomic shift in stromal cells.
Fantasy baseball: Pirates expected to welcome Ryan...
Everything that happens in and around MLB has some additional context when viewed from a fantasy baseball perspective. From lineup changes to minor league call-ups to injuries and so much more, the news cycle will constantly affect player values in fantasy baseball. Our fantasy baseball buzz file, with contributions from our ESPN fantasy writers, aims to provide fantasy managers with the intel they need as news breaks around MLB.
Salivary microRNA Profiling of Long COVID Subjects Reveals Host-Encoded Regulators of Inflammation and Viral Persistence
Periodontal disease (PD) and SARS-CoV-2 infection converge upon shared immunoinflammatory axes, yet the molecular mechanisms underpinning their interplay remain insufficiently characterized. Herein, we delineate a comprehensive salivary microRNA (miRNA) repertoire from convalescent individuals with prior SARS-CoV-2 infection sampled 3-6 months post-diagnosis who fulfilled criteria for post-acute sequelae of COVID-19, yielding novel insights into the post-viral oral milieu. Salivary miRNA...
Mike Trout gets traded to Philly? JJ Bleday here t...
Each week in MLB is its own story -- full of surprises, both positive and negative -- and fantasy managers must decide what to believe and what not to believe moving forward. If any of these thoughts come true... don't be surprised! Don't be surprised ... if Los Angeles Angels OF Mike Trout gets traded to the Philadelphia Phillies Trout, 34, entered Thursday boasting a .240/.411/.479 line, on pace for 37 home runs and, perhaps most importantly, 159 games played.