Integrated Evaluation of Osmotic
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Integrated Evaluation of Osmotic and Antioxidant Defense Mechanisms in Cotton Genotypes Exposed to NaCl Stress
Salinity stress is one of the major abiotic factors limiting cotton productivity worldwide by inducing osmotic imbalance, oxidative stress, and metabolic disturbances in plant tissues. The present study aimed to evaluate the physiological and biochemical responses of different cotton (Gossypium hirsutum L.) genotypes under NaCl-induced salinity stress through analysis of proline accumulation, antioxidant enzyme activities, and lipid peroxidation intensity. The experiment was conducted under...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...