JMJD6

Quantitative profiling of JMJD6-catalysed lysine hydroxylation reveals residue-dependent oxygen sensitivity

Lysine hydroxylation is increasingly recognised as a widespread post-translational modification in human cells, with more than 100 modified sites identified to date. Jumonji domain-containing protein 6 (JMJD6) catalyses hydroxylation at multiple lysines within lysine-rich regions and is a major contributor to this modification across the proteome. As JMJD6 requires oxygen as a co-substrate, lysine hydroxylation has been proposed to couple oxygen availability to cellular function.