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Bricks and Minifigs Parts Ways with Franchise Owners
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Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
Gleam v1.17.0 Released
Gleam is a type safe and scalable language for the Erlang virtual machine and JavaScript runtimes. Today Gleam v1.17.0 has been published. But first: the first videos from the first ever all-Gleam conference have been released!