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Related Articles from SNS

Sunrise III data release opens rare high-altitude solar views that could sharpen space weather forecasts

Close to 100 scientists from all over Europe, the United States, and Japan are gathering this week at the Institute for Solar Physics (KIS) in Freiburg to present and discuss the first scientific results from the successful third flight of the balloon-borne solar observatory SUNRISE. KIS is a key contributor to the SUNRISE project. The meeting marks a milestone in the study of the sun by bringing together researchers from all over the world who are analyzing unprecedented new data gathered...

Phys.org 6d ago

Unraveling the Mechanism of HIV-1 Hypersusceptibility to Tenofovir Imparted by Islatravir Resistance Mutations

In response to the newly approved antiretroviral therapy (ART) islatravir (ISL), the M184V and A114S resistance mutations have emerged in the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). These mutations markedly hypersensitize RT to the globally administered ART tenofovir disoproxil fumarate (TDF). We have solved six structures - four by X-ray crystallography and two by cryo-EM - that capture the single- and double-mutant RTs during inhibitor incorporation and...

bioRxiv 8d ago